| http://purl.uniprot.org/citations/22537490 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22537490 | http://www.w3.org/2000/01/rdf-schema#comment | "Stem cells are essential for the regeneration and homeostasis of many organs, such as tooth, hair, skin, and intestine. Although human tooth regeneration is limited, a number of animals have evolved continuously growing teeth that provide models of stem cell-based organ renewal. A well-studied model is the mouse incisor, which contains dental epithelial stem cells in structures known as cervical loops. These stem cells produce progeny that proliferate and migrate along the proximo-distal axis of the incisor and differentiate into enamel-forming ameloblasts. Here, we studied the role of E-cadherin in behavior of the stem cells and their progeny. Levels of E-cadherin are highly dynamic in the incisor, such that E-cadherin is expressed in the stem cells, downregulated in the transit-amplifying cells, re-expressed in the pre-ameloblasts and then downregulated again in the ameloblasts. Conditional inactivation of E-cadherin in the cervical loop led to decreased numbers of label-retaining stem cells, increased proliferation, and decreased cell migration in the mouse incisor. Using both genetic and pharmacological approaches, we showed that Fibroblast Growth Factors regulate E-cadherin expression, cell proliferation and migration in the incisor. Together, our data indicate that E-cadherin is an important regulator of stem cells and their progeny during growth of the mouse incisor."xsd:string |
| http://purl.uniprot.org/citations/22537490 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2012.03.012"xsd:string |
| http://purl.uniprot.org/citations/22537490 | http://purl.uniprot.org/core/author | "Li C.Y."xsd:string |
| http://purl.uniprot.org/citations/22537490 | http://purl.uniprot.org/core/author | "McMahon M."xsd:string |
| http://purl.uniprot.org/citations/22537490 | http://purl.uniprot.org/core/author | "Cha W."xsd:string |
| http://purl.uniprot.org/citations/22537490 | http://purl.uniprot.org/core/author | "Mitsiadis T.A."xsd:string |
| http://purl.uniprot.org/citations/22537490 | http://purl.uniprot.org/core/author | "Klein O.D."xsd:string |
| http://purl.uniprot.org/citations/22537490 | http://purl.uniprot.org/core/author | "Charles R.P."xsd:string |
| http://purl.uniprot.org/citations/22537490 | http://purl.uniprot.org/core/author | "Luder H.U."xsd:string |
| http://purl.uniprot.org/citations/22537490 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22537490 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/22537490 | http://purl.uniprot.org/core/pages | "357-366"xsd:string |
| http://purl.uniprot.org/citations/22537490 | http://purl.uniprot.org/core/title | "E-cadherin regulates the behavior and fate of epithelial stem cells and their progeny in the mouse incisor."xsd:string |
| http://purl.uniprot.org/citations/22537490 | http://purl.uniprot.org/core/volume | "366"xsd:string |
| http://purl.uniprot.org/citations/22537490 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22537490 |
| http://purl.uniprot.org/citations/22537490 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22537490 |
| http://purl.uniprot.org/uniprot/#_D4Q8H8-mappedCitation-22537490 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22537490 |
| http://purl.uniprot.org/uniprot/#_D4Q8I4-mappedCitation-22537490 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22537490 |
| http://purl.uniprot.org/uniprot/#_A0A0R4IZW5-mappedCitation-22537490 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22537490 |
| http://purl.uniprot.org/uniprot/#_A2RRI7-mappedCitation-22537490 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22537490 |
| http://purl.uniprot.org/uniprot/#_B2RS85-mappedCitation-22537490 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22537490 |
| http://purl.uniprot.org/uniprot/#_A2RRI6-mappedCitation-22537490 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22537490 |
| http://purl.uniprot.org/uniprot/#_O35565-mappedCitation-22537490 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22537490 |
| http://purl.uniprot.org/uniprot/#_P09803-mappedCitation-22537490 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22537490 |