| http://purl.uniprot.org/citations/22542975 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22542975 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22542975 | http://www.w3.org/2000/01/rdf-schema#comment | "VP8 is the most abundant tegument protein of bovine herpesvirus-1 (BHV-1). In the present study DNA damage binding protein 1 (DDB1) was identified as interacting partner of VP8. MALDI-TOF mass spectroscopy analysis of proteins co-immunoprecipitated with VP8 identified DDB1 as a protein interacting with VP8. The interaction between VP8 and DDB1 was confirmed based on co-immunoprecipitation and co-localization in both VP8-transfected and BHV-1 infected cells. DDB1 was distributed both in the nucleus and the cytoplasm with some nuclear speckles prior to BHV-1 infection, became perinuclear by 4h and was predominantly nuclear at 5h post infection, where it co-localized with VP8. In contrast, in cells infected with a U(L)47 deletion mutant DDB1 remained cytoplasmic throughout the course of infection. This suggests that VP8 mediates nuclear re-localization of DDB1. Finally, VP8 was shown to be monoubiquitinated both in VP8-transfected and BHV-1-infected cells. These data suggest that BHV-1 VP8 interacts with DDB1-CUL4 E3 ubiquitin ligase, which correlates to monoubiquitination of this viral protein."xsd:string |
| http://purl.uniprot.org/citations/22542975 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.virusres.2012.04.005"xsd:string |
| http://purl.uniprot.org/citations/22542975 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.virusres.2012.04.005"xsd:string |
| http://purl.uniprot.org/citations/22542975 | http://purl.uniprot.org/core/author | "Babiuk L.A."xsd:string |
| http://purl.uniprot.org/citations/22542975 | http://purl.uniprot.org/core/author | "Babiuk L.A."xsd:string |
| http://purl.uniprot.org/citations/22542975 | http://purl.uniprot.org/core/author | "van Drunen Littel-van den Hurk S."xsd:string |
| http://purl.uniprot.org/citations/22542975 | http://purl.uniprot.org/core/author | "van Drunen Littel-van den Hurk S."xsd:string |
| http://purl.uniprot.org/citations/22542975 | http://purl.uniprot.org/core/author | "Labiuk S.L."xsd:string |
| http://purl.uniprot.org/citations/22542975 | http://purl.uniprot.org/core/author | "Labiuk S.L."xsd:string |
| http://purl.uniprot.org/citations/22542975 | http://purl.uniprot.org/core/author | "Lobanov V.A."xsd:string |
| http://purl.uniprot.org/citations/22542975 | http://purl.uniprot.org/core/author | "Lobanov V.A."xsd:string |
| http://purl.uniprot.org/citations/22542975 | http://purl.uniprot.org/core/author | "Snider M."xsd:string |
| http://purl.uniprot.org/citations/22542975 | http://purl.uniprot.org/core/author | "Snider M."xsd:string |
| http://purl.uniprot.org/citations/22542975 | http://purl.uniprot.org/core/author | "Vasilenko N.L."xsd:string |
| http://purl.uniprot.org/citations/22542975 | http://purl.uniprot.org/core/author | "Vasilenko N.L."xsd:string |
| http://purl.uniprot.org/citations/22542975 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22542975 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22542975 | http://purl.uniprot.org/core/name | "Virus Res."xsd:string |
| http://purl.uniprot.org/citations/22542975 | http://purl.uniprot.org/core/name | "Virus Res."xsd:string |
| http://purl.uniprot.org/citations/22542975 | http://purl.uniprot.org/core/pages | "56-66"xsd:string |
| http://purl.uniprot.org/citations/22542975 | http://purl.uniprot.org/core/pages | "56-66"xsd:string |
| http://purl.uniprot.org/citations/22542975 | http://purl.uniprot.org/core/title | "Bovine herpesvirus-1 VP8 interacts with DNA damage binding protein-1 (DDB1) and is monoubiquitinated during infection."xsd:string |
| http://purl.uniprot.org/citations/22542975 | http://purl.uniprot.org/core/title | "Bovine herpesvirus-1 VP8 interacts with DNA damage binding protein-1 (DDB1) and is monoubiquitinated during infection."xsd:string |