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http://purl.uniprot.org/citations/22546946http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Purpose

To evaluate the association of HSD17B1 and HSD17B2 gene polymorphisms with uterine leiomyoma in Chinese women.

Methods

121 Chinese women with clinically diagnosed uterine leiomyoma and 217 healthy normal Chinese women were investigated to compare three single nucleotide polymorphisms (SNPs) (rs605059 and rs676387 of HSD17B1 gene and rs8191246 of HSD17B2 gene) by polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing method.

Results

All the SNPs were polymorphisms in Chinese women. Frequencies of rs605059 AA genotype and A allele were significantly increased in patients with uterine leiomyoma compared to healthy controls (GG vs. AA, OR 0.40, 95 % CI 0.20-0.82; G vs. A, OR 0.68, 95 % CI 0.50-0.94).

Conclusion

The results suggest that the genotype of HSD17B1 rs605059 may play a role in the tumourgenesis of uterine leiomyoma."xsd:string
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http://purl.uniprot.org/citations/22546946http://purl.uniprot.org/core/author"Cong L."xsd:string
http://purl.uniprot.org/citations/22546946http://purl.uniprot.org/core/author"Wang Z."xsd:string
http://purl.uniprot.org/citations/22546946http://purl.uniprot.org/core/author"Yan J."xsd:string
http://purl.uniprot.org/citations/22546946http://purl.uniprot.org/core/author"Ye Y."xsd:string
http://purl.uniprot.org/citations/22546946http://purl.uniprot.org/core/author"Zha L."xsd:string
http://purl.uniprot.org/citations/22546946http://purl.uniprot.org/core/author"Huang Z.Y."xsd:string
http://purl.uniprot.org/citations/22546946http://purl.uniprot.org/core/author"Li Y.B."xsd:string
http://purl.uniprot.org/citations/22546946http://purl.uniprot.org/core/author"Cao L.P."xsd:string
http://purl.uniprot.org/citations/22546946http://purl.uniprot.org/core/author"Su X.W."xsd:string
http://purl.uniprot.org/citations/22546946http://purl.uniprot.org/core/author"Cong R.J."xsd:string
http://purl.uniprot.org/citations/22546946http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/22546946http://purl.uniprot.org/core/name"Arch Gynecol Obstet"xsd:string
http://purl.uniprot.org/citations/22546946http://purl.uniprot.org/core/pages"701-705"xsd:string
http://purl.uniprot.org/citations/22546946http://purl.uniprot.org/core/title"Polymorphisms in genes HSD17B1 and HSD17B2 and uterine leiomyoma risk in Chinese women."xsd:string
http://purl.uniprot.org/citations/22546946http://purl.uniprot.org/core/volume"286"xsd:string
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