| http://purl.uniprot.org/citations/22547677 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22547677 | http://www.w3.org/2000/01/rdf-schema#comment | "The packaging of DNA into nucleosomes imposes obstacles on gene transcription, and histone-modifying and nucleosome-remodeling complexes work in concert to alleviate these obstacles so as to facilitate transcription. Emerging evidence shows that chromatin-associated poly(ADP-ribose) polymerase 1 (PARP-1) and its enzymatic activity facilitate inflammatory gene transcription and modulate the inflammatory response in animal models. However, the molecular mechanisms by which PARP-1 enzymatic activity facilitates transcription are not well understood. Here we show that through an intracellular signaling pathway, lipopolysaccharide (LPS) stimulation induces PARP-1 enzymatic activity and the ADP-ribosylation of histones at transcriptionally active and accessible chromatin regions in macrophages. In vitro DNase I footprinting and restriction endonuclease accessibility assays reveal that histone ADP-ribosylation directly destabilizes histone-DNA interactions in the nucleosome and increases the site accessibility of the nucleosomal DNA to nucleases. Consistent with this, LPS stimulation-induced ADP-ribosylation at the nucleosome-occupied promoters of il-1β, mip-2, and csf2 facilitates NF-κB recruitment and the transcription of these genes in macrophages. Therefore, our data suggest that PARP-1 enzymatic activity facilitates gene transcription through increasing promoter accessibility by histone ADP-ribosylation."xsd:string |
| http://purl.uniprot.org/citations/22547677 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.06667-11"xsd:string |
| http://purl.uniprot.org/citations/22547677 | http://purl.uniprot.org/core/author | "Ha H.C."xsd:string |
| http://purl.uniprot.org/citations/22547677 | http://purl.uniprot.org/core/author | "Martinez-Zamudio R."xsd:string |
| http://purl.uniprot.org/citations/22547677 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22547677 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/22547677 | http://purl.uniprot.org/core/pages | "2490-2502"xsd:string |
| http://purl.uniprot.org/citations/22547677 | http://purl.uniprot.org/core/title | "Histone ADP-ribosylation facilitates gene transcription by directly remodeling nucleosomes."xsd:string |
| http://purl.uniprot.org/citations/22547677 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/22547677 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22547677 |
| http://purl.uniprot.org/citations/22547677 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22547677 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVX0-mappedCitation-22547677 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22547677 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YX03-mappedCitation-22547677 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22547677 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YY63-mappedCitation-22547677 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22547677 |
| http://purl.uniprot.org/uniprot/#_P11103-mappedCitation-22547677 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22547677 |
| http://purl.uniprot.org/uniprot/#_Q3U868-mappedCitation-22547677 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22547677 |
| http://purl.uniprot.org/uniprot/#_Q3TX36-mappedCitation-22547677 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22547677 |
| http://purl.uniprot.org/uniprot/#_Q921K2-mappedCitation-22547677 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22547677 |
| http://purl.uniprot.org/uniprot/#_Q3UJ03-mappedCitation-22547677 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22547677 |
| http://purl.uniprot.org/uniprot/#_Q3TF18-mappedCitation-22547677 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22547677 |
| http://purl.uniprot.org/uniprot/#_Q3TIV3-mappedCitation-22547677 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22547677 |
| http://purl.uniprot.org/uniprot/#_Q3TM68-mappedCitation-22547677 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22547677 |
| http://purl.uniprot.org/uniprot/#_Q3UX06-mappedCitation-22547677 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22547677 |
| http://purl.uniprot.org/uniprot/A0A0A6YY63 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22547677 |