| http://purl.uniprot.org/citations/22547703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22547703 | http://www.w3.org/2000/01/rdf-schema#comment | "To test the hypothesis that DNA polymerase ζ participates in Ig hypermutation, we generated two mouse models of Pol ζ function: a B cell-specific conditional knockout and a knock-in strain with a Pol ζ mutagenesis-enhancing mutation. Pol ζ-deficient B cells had a reduction in mutation frequency at Ig loci in the spleen and in Peyer's patches, whereas knock-in mice with a mutagenic Pol ζ displayed a marked increase in mutation frequency in Peyer's patches, revealing a pattern that was similar to mutations in yeast strains with a homologous mutation in the gene encoding the catalytic subunit of Pol ζ. Combined, these data are best explained by a direct role for DNA polymerase ζ in Ig hypermutation."xsd:string |
| http://purl.uniprot.org/citations/22547703 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1102629"xsd:string |
| http://purl.uniprot.org/citations/22547703 | http://purl.uniprot.org/core/author | "Bebenek K."xsd:string |
| http://purl.uniprot.org/citations/22547703 | http://purl.uniprot.org/core/author | "Kunkel T.A."xsd:string |
| http://purl.uniprot.org/citations/22547703 | http://purl.uniprot.org/core/author | "Jiang C."xsd:string |
| http://purl.uniprot.org/citations/22547703 | http://purl.uniprot.org/core/author | "Richter K."xsd:string |
| http://purl.uniprot.org/citations/22547703 | http://purl.uniprot.org/core/author | "Diaz M."xsd:string |
| http://purl.uniprot.org/citations/22547703 | http://purl.uniprot.org/core/author | "Zhao M.L."xsd:string |
| http://purl.uniprot.org/citations/22547703 | http://purl.uniprot.org/core/author | "Ray M."xsd:string |
| http://purl.uniprot.org/citations/22547703 | http://purl.uniprot.org/core/author | "McGregor W.G."xsd:string |
| http://purl.uniprot.org/citations/22547703 | http://purl.uniprot.org/core/author | "Daly J."xsd:string |
| http://purl.uniprot.org/citations/22547703 | http://purl.uniprot.org/core/author | "Watt D.L."xsd:string |
| http://purl.uniprot.org/citations/22547703 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22547703 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/22547703 | http://purl.uniprot.org/core/pages | "5528-5537"xsd:string |
| http://purl.uniprot.org/citations/22547703 | http://purl.uniprot.org/core/title | "Altered Ig hypermutation pattern and frequency in complementary mouse models of DNA polymerase zeta activity."xsd:string |
| http://purl.uniprot.org/citations/22547703 | http://purl.uniprot.org/core/volume | "188"xsd:string |
| http://purl.uniprot.org/citations/22547703 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22547703 |
| http://purl.uniprot.org/citations/22547703 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22547703 |
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| http://purl.uniprot.org/uniprot/#_C4TNX1-mappedCitation-22547703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22547703 |
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| http://purl.uniprot.org/uniprot/#_C4B7Q4-mappedCitation-22547703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22547703 |