| http://purl.uniprot.org/citations/22549958 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22549958 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22549958 | http://www.w3.org/2000/01/rdf-schema#comment | "Meiotic crossover formation involves the repair of programmed DNA double-strand breaks (DSBs) and synaptonemal complex (SC) formation. Completion of these processes must precede the meiotic divisions in order to avoid chromosome abnormalities in gametes. Enduring key questions in meiosis have been how meiotic progression and crossover formation are coordinated, whether inappropriate asynapsis is monitored, and whether asynapsis elicits prophase arrest via mechanisms that are distinct from the surveillance of unrepaired DNA DSBs. We disrupted the meiosis-specific mouse HORMAD2 (Hop1, Rev7, and Mad2 domain 2) protein, which preferentially associates with unsynapsed chromosome axes. We show that HORMAD2 is required for the accumulation of the checkpoint kinase ATR along unsynapsed axes, but not at DNA DSBs or on DNA DSB-associated chromatin loops. Consistent with the hypothesis that ATR activity on chromatin plays important roles in the quality control of meiotic prophase, HORMAD2 is required for the elimination of the asynaptic Spo11(-/-), but not the asynaptic and DSB repair-defective Dmc1(-/-) oocytes. Our observations strongly suggest that HORMAD2-dependent recruitment of ATR to unsynapsed chromosome axes constitutes a mechanism for the surveillance of asynapsis. Thus, we provide convincing evidence for the existence of a distinct asynapsis surveillance mechanism that safeguards the ploidy of the mammalian germline."xsd:string |
| http://purl.uniprot.org/citations/22549958 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.187559.112"xsd:string |
| http://purl.uniprot.org/citations/22549958 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.187559.112"xsd:string |
| http://purl.uniprot.org/citations/22549958 | http://purl.uniprot.org/core/author | "Baumann M."xsd:string |
| http://purl.uniprot.org/citations/22549958 | http://purl.uniprot.org/core/author | "Baumann M."xsd:string |
| http://purl.uniprot.org/citations/22549958 | http://purl.uniprot.org/core/author | "Varga J."xsd:string |
| http://purl.uniprot.org/citations/22549958 | http://purl.uniprot.org/core/author | "Varga J."xsd:string |
| http://purl.uniprot.org/citations/22549958 | http://purl.uniprot.org/core/author | "Fu J."xsd:string |
| http://purl.uniprot.org/citations/22549958 | http://purl.uniprot.org/core/author | "Fu J."xsd:string |
| http://purl.uniprot.org/citations/22549958 | http://purl.uniprot.org/core/author | "Toth A."xsd:string |
| http://purl.uniprot.org/citations/22549958 | http://purl.uniprot.org/core/author | "Toth A."xsd:string |
| http://purl.uniprot.org/citations/22549958 | http://purl.uniprot.org/core/author | "Stewart A.F."xsd:string |
| http://purl.uniprot.org/citations/22549958 | http://purl.uniprot.org/core/author | "Stewart A.F."xsd:string |
| http://purl.uniprot.org/citations/22549958 | http://purl.uniprot.org/core/author | "Turner J.M."xsd:string |
| http://purl.uniprot.org/citations/22549958 | http://purl.uniprot.org/core/author | "Turner J.M."xsd:string |
| http://purl.uniprot.org/citations/22549958 | http://purl.uniprot.org/core/author | "Anastassiadis K."xsd:string |
| http://purl.uniprot.org/citations/22549958 | http://purl.uniprot.org/core/author | "Anastassiadis K."xsd:string |
| http://purl.uniprot.org/citations/22549958 | http://purl.uniprot.org/core/author | "Cloutier J.M."xsd:string |
| http://purl.uniprot.org/citations/22549958 | http://purl.uniprot.org/core/author | "Cloutier J.M."xsd:string |
| http://purl.uniprot.org/citations/22549958 | http://purl.uniprot.org/core/author | "Daniel K."xsd:string |
| http://purl.uniprot.org/citations/22549958 | http://purl.uniprot.org/core/author | "Daniel K."xsd:string |
| http://purl.uniprot.org/citations/22549958 | http://purl.uniprot.org/core/author | "Remenyi A."xsd:string |
| http://purl.uniprot.org/citations/22549958 | http://purl.uniprot.org/core/author | "Remenyi A."xsd:string |