| http://purl.uniprot.org/citations/22552229 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22552229 | http://www.w3.org/2000/01/rdf-schema#comment | "The autoimmune regulator (Aire) plays a critical role in central tolerance by promoting the display of tissue-specific antigens in the thymus. To study the influence of Aire on thymic selection in a physiological setting, we used tetramer reagents to detect autoreactive T cells specific for the Aire-dependent tissue-specific antigen interphotoreceptor retinoid-binding protein (IRBP), in the polyclonal repertoire. Two class II tetramer reagents were designed to identify T cells specific for two different peptide epitopes of IRBP. Analyses of the polyclonal T-cell repertoire showed a high frequency of activated T cells specific for both IRBP tetramers in Aire(-/-) mice, but not in Aire(+/+) mice. Surprisingly, although one tetramer-binding T-cell population was efficiently deleted in the thymus in an Aire-dependent manner, the second tetramer-binding population was not deleted and could be detected in both the Aire(-/-) and Aire(+/+) T-cell repertoires. We found that Aire-dependent thymic deletion of IRBP-specific T cells relies on intercellular transfer of IRBP between thymic stroma and bone marrow-derived antigen-presenting cells. Furthermore, our data suggest that Aire-mediated deletion relies not only on thymic expression of IRBP, but also on proper antigen processing and presentation of IRBP by thymic antigen-presenting cells."xsd:string |
| http://purl.uniprot.org/citations/22552229 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1120607109"xsd:string |
| http://purl.uniprot.org/citations/22552229 | http://purl.uniprot.org/core/author | "Anderson M.S."xsd:string |
| http://purl.uniprot.org/citations/22552229 | http://purl.uniprot.org/core/author | "Sette A."xsd:string |
| http://purl.uniprot.org/citations/22552229 | http://purl.uniprot.org/core/author | "Sidney J."xsd:string |
| http://purl.uniprot.org/citations/22552229 | http://purl.uniprot.org/core/author | "Jenkins M.K."xsd:string |
| http://purl.uniprot.org/citations/22552229 | http://purl.uniprot.org/core/author | "Moon J.J."xsd:string |
| http://purl.uniprot.org/citations/22552229 | http://purl.uniprot.org/core/author | "DeVoss J.J."xsd:string |
| http://purl.uniprot.org/citations/22552229 | http://purl.uniprot.org/core/author | "Taniguchi R.T."xsd:string |
| http://purl.uniprot.org/citations/22552229 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22552229 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/22552229 | http://purl.uniprot.org/core/pages | "7847-7852"xsd:string |
| http://purl.uniprot.org/citations/22552229 | http://purl.uniprot.org/core/title | "Detection of an autoreactive T-cell population within the polyclonal repertoire that undergoes distinct autoimmune regulator (Aire)-mediated selection."xsd:string |
| http://purl.uniprot.org/citations/22552229 | http://purl.uniprot.org/core/volume | "109"xsd:string |
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