| http://purl.uniprot.org/citations/22553210 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22553210 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22553210 | http://www.w3.org/2000/01/rdf-schema#comment | "Multinucleated muscle fibres arise by fusion of precursor cells called myoblasts. We previously showed that CKIP-1 ectopic expression in C2C12 myoblasts increased cell fusion. In this work, we report that CKIP-1 depletion drastically impairs C2C12 myoblast fusion in vitro and in vivo during zebrafish muscle development. Within developing fast-twich myotome, Ckip-1 localises at the periphery of fast precursor cells, closed to the plasma membrane. Unlike wild-type myoblasts that form spatially arrayed multinucleated fast myofibres, Ckip-1-deficient myoblasts show a drastic reduction in fusion capacity. A search for CKIP-1 binding partners identified the ARPC1 subunit of Arp2/3 actin nucleation complex essential for myoblast fusion. We demonstrate that CKIP-1, through binding to plasma membrane phosphoinositides via its PH domain, regulates cell morphology and lamellipodia formation by recruiting the Arp2/3 complex at the plasma membrane. These results establish CKIP-1 as a regulator of cortical actin that recruits the Arp2/3 complex at the plasma membrane essential for muscle precursor elongation and fusion."xsd:string |
| http://purl.uniprot.org/citations/22553210 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.101048"xsd:string |
| http://purl.uniprot.org/citations/22553210 | http://purl.uniprot.org/core/author | "Vidal M."xsd:string |
| http://purl.uniprot.org/citations/22553210 | http://purl.uniprot.org/core/author | "Vidal M."xsd:string |
| http://purl.uniprot.org/citations/22553210 | http://purl.uniprot.org/core/author | "Hill D.E."xsd:string |
| http://purl.uniprot.org/citations/22553210 | http://purl.uniprot.org/core/author | "Hill D.E."xsd:string |
| http://purl.uniprot.org/citations/22553210 | http://purl.uniprot.org/core/author | "Vernay A."xsd:string |
| http://purl.uniprot.org/citations/22553210 | http://purl.uniprot.org/core/author | "Vernay A."xsd:string |
| http://purl.uniprot.org/citations/22553210 | http://purl.uniprot.org/core/author | "Bertrand S."xsd:string |
| http://purl.uniprot.org/citations/22553210 | http://purl.uniprot.org/core/author | "Bertrand S."xsd:string |
| http://purl.uniprot.org/citations/22553210 | http://purl.uniprot.org/core/author | "Jurdic P."xsd:string |
| http://purl.uniprot.org/citations/22553210 | http://purl.uniprot.org/core/author | "Jurdic P."xsd:string |
| http://purl.uniprot.org/citations/22553210 | http://purl.uniprot.org/core/author | "Goillot E."xsd:string |
| http://purl.uniprot.org/citations/22553210 | http://purl.uniprot.org/core/author | "Goillot E."xsd:string |
| http://purl.uniprot.org/citations/22553210 | http://purl.uniprot.org/core/author | "Schaeffer L."xsd:string |
| http://purl.uniprot.org/citations/22553210 | http://purl.uniprot.org/core/author | "Schaeffer L."xsd:string |
| http://purl.uniprot.org/citations/22553210 | http://purl.uniprot.org/core/author | "Rual J.F."xsd:string |
| http://purl.uniprot.org/citations/22553210 | http://purl.uniprot.org/core/author | "Rual J.F."xsd:string |
| http://purl.uniprot.org/citations/22553210 | http://purl.uniprot.org/core/author | "Chopin E."xsd:string |
| http://purl.uniprot.org/citations/22553210 | http://purl.uniprot.org/core/author | "Chopin E."xsd:string |
| http://purl.uniprot.org/citations/22553210 | http://purl.uniprot.org/core/author | "Baas D."xsd:string |
| http://purl.uniprot.org/citations/22553210 | http://purl.uniprot.org/core/author | "Baas D."xsd:string |
| http://purl.uniprot.org/citations/22553210 | http://purl.uniprot.org/core/author | "Guiraud A."xsd:string |