| http://purl.uniprot.org/citations/22558447 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22558447 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundNotch signaling is a highly conserved pathway in multi-cellular organisms ranging from flies to humans. It controls a variety of developmental processes by stimulating the expression of its target genes in a highly specific manner both spatially and temporally. The diversity, specificity and sensitivity of the Notch signaling output are regulated at distinct levels, particularly at the level of ligand-receptor interactions.Methodology/principal findingsHere, we report that the Drosophila gene uninflatable (uif), which encodes a large transmembrane protein with eighteen EGF-like repeats in its extracellular domain, can antagonize the canonical Notch signaling pathway. Overexpression of Uif or ectopic expression of a neomorphic form of Uif, Uif*, causes Notch signaling defects in both the wing and the sensory organ precursors. Further experiments suggest that ectopic expression of Uif* inhibits Notch signaling in cis and acts at a step that is dependent on the extracellular domain of Notch. Our results suggest that Uif can alter the accessibility of the Notch extracellular domain to its ligands during Notch activation.Conclusions/significanceOur study shows that Uif can modulate Notch activity, illustrating the importance of a delicate regulation of this signaling pathway for normal patterning."xsd:string |
| http://purl.uniprot.org/citations/22558447 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0036362"xsd:string |
| http://purl.uniprot.org/citations/22558447 | http://purl.uniprot.org/core/author | "Huang Q."xsd:string |
| http://purl.uniprot.org/citations/22558447 | http://purl.uniprot.org/core/author | "Liang X."xsd:string |
| http://purl.uniprot.org/citations/22558447 | http://purl.uniprot.org/core/author | "Ma J."xsd:string |
| http://purl.uniprot.org/citations/22558447 | http://purl.uniprot.org/core/author | "Xie G."xsd:string |
| http://purl.uniprot.org/citations/22558447 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/22558447 | http://purl.uniprot.org/core/author | "Du G."xsd:string |
| http://purl.uniprot.org/citations/22558447 | http://purl.uniprot.org/core/author | "Jiao R."xsd:string |
| http://purl.uniprot.org/citations/22558447 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22558447 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/22558447 | http://purl.uniprot.org/core/pages | "e36362"xsd:string |
| http://purl.uniprot.org/citations/22558447 | http://purl.uniprot.org/core/title | "Uif, a large transmembrane protein with EGF-like repeats, can antagonize Notch signaling in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/22558447 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/22558447 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22558447 |
| http://purl.uniprot.org/citations/22558447 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22558447 |
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