| http://purl.uniprot.org/citations/22561013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22561013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22561013 | http://www.w3.org/2000/01/rdf-schema#comment | "rv1098c, an essential gene in Mycobacterium tuberculosis, codes for a class II fumarase. We describe here the crystal structure of Rv1098c in complex with l-malate, fumarate or the competitive inhibitor meso-tartrate. The models reveal that substrate binding promotes the closure of the active site through conformational changes involving the catalytic SS-loop and the C-terminal domain, which likely represents a general feature of this enzyme superfamily. Analysis of ligand-enzyme interactions as well as site-directed mutagenesis suggest Ser318 as one of the two acid-base catalysts."xsd:string |
| http://purl.uniprot.org/citations/22561013 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2012.04.034"xsd:string |
| http://purl.uniprot.org/citations/22561013 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2012.04.034"xsd:string |
| http://purl.uniprot.org/citations/22561013 | http://purl.uniprot.org/core/author | "Shepard W."xsd:string |
| http://purl.uniprot.org/citations/22561013 | http://purl.uniprot.org/core/author | "Shepard W."xsd:string |
| http://purl.uniprot.org/citations/22561013 | http://purl.uniprot.org/core/author | "Alzari P.M."xsd:string |
| http://purl.uniprot.org/citations/22561013 | http://purl.uniprot.org/core/author | "Alzari P.M."xsd:string |
| http://purl.uniprot.org/citations/22561013 | http://purl.uniprot.org/core/author | "Haouz A."xsd:string |
| http://purl.uniprot.org/citations/22561013 | http://purl.uniprot.org/core/author | "Haouz A."xsd:string |
| http://purl.uniprot.org/citations/22561013 | http://purl.uniprot.org/core/author | "Barilone N."xsd:string |
| http://purl.uniprot.org/citations/22561013 | http://purl.uniprot.org/core/author | "Barilone N."xsd:string |
| http://purl.uniprot.org/citations/22561013 | http://purl.uniprot.org/core/author | "Bellinzoni M."xsd:string |
| http://purl.uniprot.org/citations/22561013 | http://purl.uniprot.org/core/author | "Bellinzoni M."xsd:string |
| http://purl.uniprot.org/citations/22561013 | http://purl.uniprot.org/core/author | "Mechaly A.E."xsd:string |
| http://purl.uniprot.org/citations/22561013 | http://purl.uniprot.org/core/author | "Mechaly A.E."xsd:string |
| http://purl.uniprot.org/citations/22561013 | http://purl.uniprot.org/core/author | "Miras I."xsd:string |
| http://purl.uniprot.org/citations/22561013 | http://purl.uniprot.org/core/author | "Miras I."xsd:string |
| http://purl.uniprot.org/citations/22561013 | http://purl.uniprot.org/core/author | "Weber P."xsd:string |
| http://purl.uniprot.org/citations/22561013 | http://purl.uniprot.org/core/author | "Weber P."xsd:string |
| http://purl.uniprot.org/citations/22561013 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22561013 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22561013 | http://purl.uniprot.org/core/name | "FEBS Lett."xsd:string |
| http://purl.uniprot.org/citations/22561013 | http://purl.uniprot.org/core/name | "FEBS Lett."xsd:string |