| http://purl.uniprot.org/citations/22561348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22561348 | http://www.w3.org/2000/01/rdf-schema#comment | "Integrin functions are controlled by regulating their affinity for ligand, and by the efficient recycling of intact integrins through endosomes. Here we demonstrate that the Kindlin-binding site in the β1-integrin cytoplasmic domain serves as a molecular switch enabling the sequential binding of two FERM-domain-containing proteins in different cellular compartments. When β1 integrins are at the plasma membrane, Kindlins control ligand-binding affinity. However, when they are internalized, Kindlins dissociate from integrins and sorting nexin 17 (SNX17) is recruited to free β1-integrin tails in early endosomes to prevent β1-integrin degradation, leading to their recycling back to the cell surface. Our results identify SNX17 as a β1-integrin-tail-binding protein that interacts with the free Kindlin-binding site in endosomes to stabilize β1 integrins, resulting in their recycling to the cell surface where they can be reused."xsd:string |
| http://purl.uniprot.org/citations/22561348 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb2501"xsd:string |
| http://purl.uniprot.org/citations/22561348 | http://purl.uniprot.org/core/author | "Meyer H."xsd:string |
| http://purl.uniprot.org/citations/22561348 | http://purl.uniprot.org/core/author | "Fassler R."xsd:string |
| http://purl.uniprot.org/citations/22561348 | http://purl.uniprot.org/core/author | "Widmaier M."xsd:string |
| http://purl.uniprot.org/citations/22561348 | http://purl.uniprot.org/core/author | "Bottcher R.T."xsd:string |
| http://purl.uniprot.org/citations/22561348 | http://purl.uniprot.org/core/author | "Tseng H.Y."xsd:string |
| http://purl.uniprot.org/citations/22561348 | http://purl.uniprot.org/core/author | "Meves A."xsd:string |
| http://purl.uniprot.org/citations/22561348 | http://purl.uniprot.org/core/author | "Stremmel C."xsd:string |
| http://purl.uniprot.org/citations/22561348 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22561348 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/22561348 | http://purl.uniprot.org/core/pages | "584-592"xsd:string |
| http://purl.uniprot.org/citations/22561348 | http://purl.uniprot.org/core/title | "Sorting nexin 17 prevents lysosomal degradation of beta1 integrins by binding to the beta1-integrin tail."xsd:string |
| http://purl.uniprot.org/citations/22561348 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/22561348 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22561348 |
| http://purl.uniprot.org/citations/22561348 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22561348 |
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