| http://purl.uniprot.org/citations/22569063 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22569063 | http://www.w3.org/2000/01/rdf-schema#comment | "Limited functional imaging evidence suggests that increased beta-amyloid deposition is associated with alterations in brain function, even in healthy older adults. However, the majority of these findings report on resting-state activity or functional connectivity in adults over age 60. Much less is known about the impact of beta-amyloid on neural activations during cognitive task performance, or the impact of amyloid in young and middle-aged adults. The current study measured beta-amyloid burden from PET imaging using (18)Florbetapir, in a large continuous age sample of highly-screened, healthy adults (N=137; aged 30-89 years). The same participants also underwent fMRI scanning, performing a memory encoding task. Using both beta-amyloid burden and age as continuous predictors of encoding activity, we report a dose-response relationship of beta-amyloid load to neural function, beyond the effects of age. Specifically, individuals with greater amyloid burden evidence less neural activation in bilateral dorsolateral prefrontal cortex, a region important for memory encoding, as well as reduced neural modulation in areas associated with default network activity: bilateral superior/medial frontal and lateral temporal cortex. Importantly, this reduction of both activation and suppression as a function of amyloid load was found across the lifespan, even in young- and middle-aged individuals. Moreover, this frontal and temporal amyloid-reduced activation/suppression was associated with poorer processing speed, verbal fluency, and fluid reasoning in a subgroup of individuals with elevated amyloid, suggesting that it is detrimental, rather than compensatory in nature."xsd:string |
| http://purl.uniprot.org/citations/22569063 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuroimage.2012.03.077"xsd:string |
| http://purl.uniprot.org/citations/22569063 | http://purl.uniprot.org/core/author | "Park D.C."xsd:string |
| http://purl.uniprot.org/citations/22569063 | http://purl.uniprot.org/core/author | "Kennedy K.M."xsd:string |
| http://purl.uniprot.org/citations/22569063 | http://purl.uniprot.org/core/author | "Rodrigue K.M."xsd:string |
| http://purl.uniprot.org/citations/22569063 | http://purl.uniprot.org/core/author | "Bischof G.N."xsd:string |
| http://purl.uniprot.org/citations/22569063 | http://purl.uniprot.org/core/author | "Devous M.D. Sr."xsd:string |
| http://purl.uniprot.org/citations/22569063 | http://purl.uniprot.org/core/author | "Hebrank A.C."xsd:string |
| http://purl.uniprot.org/citations/22569063 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22569063 | http://purl.uniprot.org/core/name | "Neuroimage"xsd:string |
| http://purl.uniprot.org/citations/22569063 | http://purl.uniprot.org/core/pages | "1-8"xsd:string |
| http://purl.uniprot.org/citations/22569063 | http://purl.uniprot.org/core/title | "Effects of beta-amyloid accumulation on neural function during encoding across the adult lifespan."xsd:string |
| http://purl.uniprot.org/citations/22569063 | http://purl.uniprot.org/core/volume | "62"xsd:string |
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