| http://purl.uniprot.org/citations/22573493 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22573493 | http://www.w3.org/2000/01/rdf-schema#comment | "MicroRNAs (miRNAs) are noncoding small RNAs that play important roles in a variety of physiological and pathological events. In this study, we performed large-scale profiling of EIF2C2-bound miRNAs in 3 human granulosa-derived cell lines (ie, KGN, HSOGT, and GC1a) by high-throughput sequencing and found that miR-21 accounted for more than 80% of EIF2C2-bound miRNAs, suggesting that it was enriched in the RNA-induced silencing complex (RISC) and played a functional role in human granulosa cell (GC) lines. We also found high expression levels of miR-21 in primary human GCs. Assuming that miR-21 target mRNAs are enriched in RISC, we performed cDNA cloning of EIF2C2-bound mRNAs in KGN cells. We identified COL4A1 mRNA as a miR-21 target in the GC lines. These data suggest that miR-21 is involved in the regulation of the synthesis of COL4A1, a component of the basement membrane surrounding the GC layer and granulosa-embedded extracellular structure."xsd:string |
| http://purl.uniprot.org/citations/22573493 | http://purl.org/dc/terms/identifier | "doi:10.1177/1933719112442245"xsd:string |
| http://purl.uniprot.org/citations/22573493 | http://purl.uniprot.org/core/author | "Ishikawa T."xsd:string |
| http://purl.uniprot.org/citations/22573493 | http://purl.uniprot.org/core/author | "Ohba T."xsd:string |
| http://purl.uniprot.org/citations/22573493 | http://purl.uniprot.org/core/author | "Takizawa T."xsd:string |
| http://purl.uniprot.org/citations/22573493 | http://purl.uniprot.org/core/author | "Ishibashi O."xsd:string |
| http://purl.uniprot.org/citations/22573493 | http://purl.uniprot.org/core/author | "Takeshita T."xsd:string |
| http://purl.uniprot.org/citations/22573493 | http://purl.uniprot.org/core/author | "Katabuchi H."xsd:string |
| http://purl.uniprot.org/citations/22573493 | http://purl.uniprot.org/core/author | "Takizawa T.'"xsd:string |
| http://purl.uniprot.org/citations/22573493 | http://purl.uniprot.org/core/author | "Kiguchi K."xsd:string |
| http://purl.uniprot.org/citations/22573493 | http://purl.uniprot.org/core/author | "Mase Y."xsd:string |
| http://purl.uniprot.org/citations/22573493 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22573493 | http://purl.uniprot.org/core/name | "Reprod Sci"xsd:string |
| http://purl.uniprot.org/citations/22573493 | http://purl.uniprot.org/core/pages | "1030-1040"xsd:string |
| http://purl.uniprot.org/citations/22573493 | http://purl.uniprot.org/core/title | "MiR-21 is enriched in the RNA-induced silencing complex and targets COL4A1 in human granulosa cell lines."xsd:string |
| http://purl.uniprot.org/citations/22573493 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/22573493 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22573493 |
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| http://purl.uniprot.org/uniprot/#_A0A6G9EL94-mappedCitation-22573493 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22573493 |
| http://purl.uniprot.org/uniprot/#_A5PKV2-mappedCitation-22573493 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22573493 |
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| http://purl.uniprot.org/uniprot/#_Q14051-mappedCitation-22573493 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22573493 |
| http://purl.uniprot.org/uniprot/#_Q59F15-mappedCitation-22573493 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22573493 |
| http://purl.uniprot.org/uniprot/#_P02462-mappedCitation-22573493 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22573493 |