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| http://purl.uniprot.org/citations/22575652 | http://www.w3.org/2000/01/rdf-schema#comment | "Addition of poly(A) to the 3' ends of cleaved pre-mRNA is essential for mRNA maturation and is catalyzed by Pap1 in yeast. We have previously shown that a non-viable Pap1 mutant lacking the first 18 amino acids is fully active for polyadenylation of oligoA, but defective for pre-mRNA polyadenylation, suggesting that interactions at the N-terminus are important for enzyme function in the processing complex. We have now identified proteins that interact specifically with this region. Cft1 and Pta1 are subunits of the cleavage/polyadenylation factor, in which Pap1 resides, and Nab6 and Sub1 are nucleic-acid binding proteins with known links to 3' end processing. Our results suggest a novel mechanism for controlling Pap1 activity, and possible models invoking these newly-discovered interactions are discussed."xsd:string |
| http://purl.uniprot.org/citations/22575652 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2012.03.036"xsd:string |
| http://purl.uniprot.org/citations/22575652 | http://purl.uniprot.org/core/author | "Moore C."xsd:string |
| http://purl.uniprot.org/citations/22575652 | http://purl.uniprot.org/core/author | "Ghazy M.A."xsd:string |
| http://purl.uniprot.org/citations/22575652 | http://purl.uniprot.org/core/author | "Yeh P.C."xsd:string |
| http://purl.uniprot.org/citations/22575652 | http://purl.uniprot.org/core/author | "Ezeokonkwo C."xsd:string |
| http://purl.uniprot.org/citations/22575652 | http://purl.uniprot.org/core/author | "Zhelkovsky A."xsd:string |
| http://purl.uniprot.org/citations/22575652 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22575652 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/22575652 | http://purl.uniprot.org/core/pages | "1173-1178"xsd:string |
| http://purl.uniprot.org/citations/22575652 | http://purl.uniprot.org/core/title | "Novel interactions at the essential N-terminus of poly(A) polymerase that could regulate poly(A) addition in Saccharomyces cerevisiae."xsd:string |
| http://purl.uniprot.org/citations/22575652 | http://purl.uniprot.org/core/volume | "586"xsd:string |
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