| http://purl.uniprot.org/citations/22578166 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22578166 | http://www.w3.org/2000/01/rdf-schema#comment | "Oxidative stress and neuroinflammation play important roles in Alzheimer's disease (AD). ABCG2 is a transporter protein expressed in the brain and involved in GSH transport. To study the roles of Abcg2 in oxidative stress and AD, we cross-bred Tg-SwDI and Abcg2-KO mice and generated Tg-SwDI/Abcg2-KO (double-tg) mice. Brain tissues from double-tg, Tg-SwDI, wild-type, and Abcg2-KO mice at various ages were analyzed. Aβ40 and Aβ42 were detected in Tg-SwDI and double-tg mice. Total brain GSH was decreased and levels of lipid/DNA oxidation were increased in 3-month double-tg compared to Tg-SwDI mice. Low brain GSH was still detected in 9-month double-tg mice. Increased HMOX-1 and MCP-5 expression was observed in 9-month double-tg mice but not in Tg-SwDI mice compared to WT and Abcg2-KO mice. Increased HMOX-1 and decreased ICAM-1 expression were observed in 12-month double-tg mice compared to Tg-SwDI mice. The levels of Nrf-2 expression and activity were decreased in 6-month double-tg mice. Behavioral tests show impaired cognitive/memory performance of 9-month double-tg compared to Tg-SwDI mice as well as WT and Abcg2-KO mice. These results suggest that Abcg2 deficiency increases oxidative stress and alters inflammatory response in the brain and exacerbates cognitive/memory deficit in double-tg mice at different developmental stages."xsd:string |
| http://purl.uniprot.org/citations/22578166 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1471-4159.2012.07783.x"xsd:string |
| http://purl.uniprot.org/citations/22578166 | http://purl.uniprot.org/core/author | "Huang P."xsd:string |
| http://purl.uniprot.org/citations/22578166 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/22578166 | http://purl.uniprot.org/core/author | "Xiong H."xsd:string |
| http://purl.uniprot.org/citations/22578166 | http://purl.uniprot.org/core/author | "Yang Z."xsd:string |
| http://purl.uniprot.org/citations/22578166 | http://purl.uniprot.org/core/author | "Zeng Y."xsd:string |
| http://purl.uniprot.org/citations/22578166 | http://purl.uniprot.org/core/author | "Callaghan D."xsd:string |
| http://purl.uniprot.org/citations/22578166 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22578166 | http://purl.uniprot.org/core/name | "J Neurochem"xsd:string |
| http://purl.uniprot.org/citations/22578166 | http://purl.uniprot.org/core/pages | "456-469"xsd:string |
| http://purl.uniprot.org/citations/22578166 | http://purl.uniprot.org/core/title | "Abcg2 deficiency augments oxidative stress and cognitive deficits in Tg-SwDI transgenic mice."xsd:string |
| http://purl.uniprot.org/citations/22578166 | http://purl.uniprot.org/core/volume | "122"xsd:string |
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