| http://purl.uniprot.org/citations/22579353 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22579353 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22579353 | http://www.w3.org/2000/01/rdf-schema#comment | "APOBEC3G (A3G) and APOBEC3F (A3F) reduce Vif-negative HIV-1 provirus formation and cause disabling provirus G-to-A hypermutation in vitro. However, evidence conflicts about whether they negatively impact Vif-positive HIV-1, or only enhance virus genetic diversity, in vivo. We studied peripheral blood mononuclear cells (PBMC) from 19 antiretroviral-naïve, HIV-infected adults: 12 long-term non-progressors (LTNP) and 7 non-controllers (NC). Cells from LTNP had higher A3G and A3F mRNA levels, lower provirus burden, and more A3G-hypermutated positions in provirus sequence than cells from NC. A3G mRNA level was directly associated with its Hypermutation Index (HI) and inversely associated with provirus burden. Plasma HIV-1 RNA levels were inversely associated with A3G expression levels and with HI only among subjects who had HI>1. A3G HI was not associated with provirus burden. These results indicate that A3G deaminase-dependent activity above a threshold level, and its deaminase-independent functions, contribute to decreasing Vif-positive virus replication in vivo."xsd:string |
| http://purl.uniprot.org/citations/22579353 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.virol.2012.03.018"xsd:string |
| http://purl.uniprot.org/citations/22579353 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.virol.2012.03.018"xsd:string |
| http://purl.uniprot.org/citations/22579353 | http://purl.uniprot.org/core/author | "McMunn C."xsd:string |
| http://purl.uniprot.org/citations/22579353 | http://purl.uniprot.org/core/author | "McMunn C."xsd:string |
| http://purl.uniprot.org/citations/22579353 | http://purl.uniprot.org/core/author | "D'Aquila R.T."xsd:string |
| http://purl.uniprot.org/citations/22579353 | http://purl.uniprot.org/core/author | "D'Aquila R.T."xsd:string |
| http://purl.uniprot.org/citations/22579353 | http://purl.uniprot.org/core/author | "Allos T."xsd:string |
| http://purl.uniprot.org/citations/22579353 | http://purl.uniprot.org/core/author | "Allos T."xsd:string |
| http://purl.uniprot.org/citations/22579353 | http://purl.uniprot.org/core/author | "De Pasquale M."xsd:string |
| http://purl.uniprot.org/citations/22579353 | http://purl.uniprot.org/core/author | "De Pasquale M."xsd:string |
| http://purl.uniprot.org/citations/22579353 | http://purl.uniprot.org/core/author | "Kourteva Y."xsd:string |
| http://purl.uniprot.org/citations/22579353 | http://purl.uniprot.org/core/author | "Kourteva Y."xsd:string |
| http://purl.uniprot.org/citations/22579353 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22579353 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22579353 | http://purl.uniprot.org/core/name | "Virology"xsd:string |
| http://purl.uniprot.org/citations/22579353 | http://purl.uniprot.org/core/name | "Virology"xsd:string |
| http://purl.uniprot.org/citations/22579353 | http://purl.uniprot.org/core/pages | "1-9"xsd:string |
| http://purl.uniprot.org/citations/22579353 | http://purl.uniprot.org/core/pages | "1-9"xsd:string |
| http://purl.uniprot.org/citations/22579353 | http://purl.uniprot.org/core/title | "APOBEC3G expression and hypermutation are inversely associated with human immunodeficiency virus type 1 (HIV-1) burden in vivo."xsd:string |
| http://purl.uniprot.org/citations/22579353 | http://purl.uniprot.org/core/title | "APOBEC3G expression and hypermutation are inversely associated with human immunodeficiency virus type 1 (HIV-1) burden in vivo."xsd:string |
| http://purl.uniprot.org/citations/22579353 | http://purl.uniprot.org/core/volume | "430"xsd:string |
| http://purl.uniprot.org/citations/22579353 | http://purl.uniprot.org/core/volume | "430"xsd:string |