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http://purl.uniprot.org/citations/22579530http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Aims

The aim of this study was to investigate whether the polymorphism of DDAH2 is associated with type 2 diabetes and hypertension in Korean population.

Methods

Total 605 subjects were included in this study: 403 patients with type 2 diabetes and 202 non-diabetic control subjects. The SNP rs805304 and rs2272592 in DDAH2 were analyzed. We examined the association of SNP rs805304 and rs2272592 in DDAH2 with type 2 diabetes and hypertension.

Results

SNP rs2272592 was significantly associated with type 2 diabetes (P<0.001) while SNP rs805304 was not (P=0.716). We observed that the prevalence of the AG+GG genotypes were significantly greater than AA homozygotes in type 2 diabetes (AA vs AG+GG; OR 20.74, 95% CI 6.48-66.35, P<0.001). Significance was maintained after adjusting for age, sex, BMI, DBP and BUN (OR 21.03, 95% CI 2.83-151.14, P=0.003). Both SNP rs805304 and rs2272592 in DDAH2 were not significantly associated with hypertension.

Conclusions

In the present study, we found that SNP rs2272592 in DDAH2 is associated with type 2 diabetes but SNP rs805304 in DDAH2 is not. DDAH2 SNP rs2272592 AG+GG genotypes are associated with genetic susceptibility to type 2 diabetes in Korean population."xsd:string
http://purl.uniprot.org/citations/22579530http://purl.org/dc/terms/identifier"doi:10.1016/j.diabres.2012.04.015"xsd:string
http://purl.uniprot.org/citations/22579530http://purl.uniprot.org/core/author"Lee I.K."xsd:string
http://purl.uniprot.org/citations/22579530http://purl.uniprot.org/core/author"Lee W.K."xsd:string
http://purl.uniprot.org/citations/22579530http://purl.uniprot.org/core/author"Kim S.W."xsd:string
http://purl.uniprot.org/citations/22579530http://purl.uniprot.org/core/author"Kim J.G."xsd:string
http://purl.uniprot.org/citations/22579530http://purl.uniprot.org/core/author"Jeon E.J."xsd:string
http://purl.uniprot.org/citations/22579530http://purl.uniprot.org/core/author"Park K.G."xsd:string
http://purl.uniprot.org/citations/22579530http://purl.uniprot.org/core/author"Jeong J.Y."xsd:string
http://purl.uniprot.org/citations/22579530http://purl.uniprot.org/core/author"Seo H.A."xsd:string
http://purl.uniprot.org/citations/22579530http://purl.uniprot.org/core/author"Moon S.S."xsd:string
http://purl.uniprot.org/citations/22579530http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/22579530http://purl.uniprot.org/core/name"Diabetes Res Clin Pract"xsd:string
http://purl.uniprot.org/citations/22579530http://purl.uniprot.org/core/pages"125-131"xsd:string
http://purl.uniprot.org/citations/22579530http://purl.uniprot.org/core/title"Association of the DDAH2 gene polymorphism with type 2 diabetes and hypertension."xsd:string
http://purl.uniprot.org/citations/22579530http://purl.uniprot.org/core/volume"98"xsd:string
http://purl.uniprot.org/citations/22579530http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/22579530
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