| http://purl.uniprot.org/citations/22579715 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22579715 | http://www.w3.org/2000/01/rdf-schema#comment | "The mitochondria-shaping protein optic atrophy 1 (OPA1) has genetically distinguishable roles in mitochondrial morphology and apoptosis. The latter depends on the presenilin associated rhomboid like (PARL) protease, essential for the accumulation of a soluble intermembrane space form of OPA1 (IMS-OPA1). Here we show that OPA1 and PARL participate in the heat shock response, a stereotypical cellular process of adaptation to thermal stress. Upon heat shock, long forms of OPA1 are lost and mitochondria fragment. However, mitochondrial fusion is dispensable to maintain viability, whereas IMS-OPA1 is required. Upon conditioning-a process of mild heat shock and recovery-IMS-OPA1 accumulates, OPA1 oligomers increase and mitochondria release less cytochrome c, ultimately resulting in cellular resistance to subsequent apoptotic inducers. In Parl(-/-) cells accumulation of IMS-OPA1 is blunted and conditioning fails to protect from cytochrome c release and apoptosis. Thus, the OPA1/PARL dependent pathway of cristae remodeling is implicated in heat shock. This article is part of a Special Issue entitled: 17th European Bioenergetics Conference (EBEC 2012)."xsd:string |
| http://purl.uniprot.org/citations/22579715 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbabio.2012.05.001"xsd:string |
| http://purl.uniprot.org/citations/22579715 | http://purl.uniprot.org/core/author | "Sanjuan Szklarz L.K."xsd:string |
| http://purl.uniprot.org/citations/22579715 | http://purl.uniprot.org/core/author | "Scorrano L."xsd:string |
| http://purl.uniprot.org/citations/22579715 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22579715 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta"xsd:string |
| http://purl.uniprot.org/citations/22579715 | http://purl.uniprot.org/core/pages | "1886-1893"xsd:string |
| http://purl.uniprot.org/citations/22579715 | http://purl.uniprot.org/core/title | "The antiapoptotic OPA1/Parl couple participates in mitochondrial adaptation to heat shock."xsd:string |
| http://purl.uniprot.org/citations/22579715 | http://purl.uniprot.org/core/volume | "1817"xsd:string |
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