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| http://purl.uniprot.org/citations/22580608 | http://www.w3.org/2000/01/rdf-schema#comment | "B-cell leukemia 3 (Bcl-3) is a member of the inhibitor of κB family, which regulates a wide range of biological processes by functioning as a transcriptional activator or as a repressor of target genes. As high levels of Bcl-3 expression and activation have been detected in different types of human cancer, Bcl-3 has been labeled a proto-oncogene. Our study uncovered a markedly upregulated Bcl-3 expression in human prostate cancer (PCa), where inflammatory cell infiltration was observed. Elevated Bcl-3 expression in PCa was dependent on the proinflammatory cytokine interleukin-6-mediated STAT3 activation. Microarray analyses, using Bcl-3 knockdown in PCa cells, identified the inhibitor of DNA-binding (Id) family of helix-loop-helix proteins as potential Bcl-3-regulated genes. Bcl-3 knockdown reduced the abundance of Id-1 and Id-2 proteins and boosted PCa cells to be more receptive to undergoing apoptosis following treatment with anticancer drug. Our data imply that inactivation of Bcl-3 may lead to sensitization of cancer cells to chemotherapeutic drug-induced apoptosis, thus suggesting a potential therapeutic strategy in PCa treatment."xsd:string |
| http://purl.uniprot.org/citations/22580608 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2012.175"xsd:string |
| http://purl.uniprot.org/citations/22580608 | http://purl.uniprot.org/core/author | "Massoumi R."xsd:string |
| http://purl.uniprot.org/citations/22580608 | http://purl.uniprot.org/core/author | "Saamarthy K."xsd:string |
| http://purl.uniprot.org/citations/22580608 | http://purl.uniprot.org/core/author | "Bjartell A."xsd:string |
| http://purl.uniprot.org/citations/22580608 | http://purl.uniprot.org/core/author | "Ahlqvist K."xsd:string |
| http://purl.uniprot.org/citations/22580608 | http://purl.uniprot.org/core/author | "Syed Khaja A.S."xsd:string |
| http://purl.uniprot.org/citations/22580608 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/22580608 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/22580608 | http://purl.uniprot.org/core/pages | "1601-1608"xsd:string |
| http://purl.uniprot.org/citations/22580608 | http://purl.uniprot.org/core/title | "Expression of Id proteins is regulated by the Bcl-3 proto-oncogene in prostate cancer."xsd:string |
| http://purl.uniprot.org/citations/22580608 | http://purl.uniprot.org/core/volume | "32"xsd:string |
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