| http://purl.uniprot.org/citations/22581856 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22581856 | http://www.w3.org/2000/01/rdf-schema#comment | "Increasing evidence suggests ion channels have critical functions in the differentiation and plasticity of T cells. Kv1.3, a voltage-gated K(+) channel, is a functional marker and a pharmacological target for activated effector memory T cells. Selective Kv1.3 blockers have been shown to inhibit proliferation and cytokine production by human and rat effector memory T cells. We used Kv1.3 knockout (KO) mice to investigate the mechanism by which Kv1.3 blockade affects CD4(+) T cell differentiation during an inflammatory immune-mediated disease. Kv1.3 KO animals displayed significantly lower incidence and severity of myelin oligodendrocyte glycoprotein (MOG) peptide-induced experimental autoimmune encephalomyelitis. Kv1.3 was the only K(V) channel expressed in MOG 35-55-specific CD4(+) T cell blasts, and no K(V) current was present in MOG-specific CD4(+) T cell-blasts from Kv1.3 KO mice. Fewer CD4(+) T cells migrated to the CNS in Kv1.3 KO mice following disease induction, and Ag-specific proliferation of CD4(+) T cells from these mice was impaired with a corresponding cell-cycle delay. Kv1.3 was required for optimal expression of IFN-γ and IL-17, whereas its absence led to increased IL-10 production. Dendritic cells from Kv1.3 KO mice fully activated wild-type CD4(+) T cells, indicating a T cell-intrinsic defect in Kv1.3 KO mice. The loss of Kv1.3 led to a suppressive phenotype, which may contribute to the mechanism by which deletion of Kv1.3 produces an immunotherapeutic effect. Skewing of CD4(+) T cell differentiation toward Ag-specific regulatory T cells by pharmacological blockade or genetic suppression of Kv1.3 might be beneficial for therapy of immune-mediated diseases such as multiple sclerosis."xsd:string |
| http://purl.uniprot.org/citations/22581856 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1103095"xsd:string |
| http://purl.uniprot.org/citations/22581856 | http://purl.uniprot.org/core/author | "Hu L."xsd:string |
| http://purl.uniprot.org/citations/22581856 | http://purl.uniprot.org/core/author | "Nguyen H.M."xsd:string |
| http://purl.uniprot.org/citations/22581856 | http://purl.uniprot.org/core/author | "Calabresi P.A."xsd:string |
| http://purl.uniprot.org/citations/22581856 | http://purl.uniprot.org/core/author | "Chandy K.G."xsd:string |
| http://purl.uniprot.org/citations/22581856 | http://purl.uniprot.org/core/author | "Whartenby K.A."xsd:string |
| http://purl.uniprot.org/citations/22581856 | http://purl.uniprot.org/core/author | "Gocke A.R."xsd:string |
| http://purl.uniprot.org/citations/22581856 | http://purl.uniprot.org/core/author | "Grishkan I.V."xsd:string |
| http://purl.uniprot.org/citations/22581856 | http://purl.uniprot.org/core/author | "Lebson L.A."xsd:string |
| http://purl.uniprot.org/citations/22581856 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22581856 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/22581856 | http://purl.uniprot.org/core/pages | "5877-5886"xsd:string |
| http://purl.uniprot.org/citations/22581856 | http://purl.uniprot.org/core/title | "Kv1.3 deletion biases T cells toward an immunoregulatory phenotype and renders mice resistant to autoimmune encephalomyelitis."xsd:string |
| http://purl.uniprot.org/citations/22581856 | http://purl.uniprot.org/core/volume | "188"xsd:string |
| http://purl.uniprot.org/citations/22581856 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22581856 |
| http://purl.uniprot.org/citations/22581856 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22581856 |
| http://purl.uniprot.org/uniprot/#_P16390-mappedCitation-22581856 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22581856 |
| http://purl.uniprot.org/uniprot/P16390 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22581856 |