| http://purl.uniprot.org/citations/22581859 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22581859 | http://www.w3.org/2000/01/rdf-schema#comment | "Inflammation is a hallmark of many important human diseases. Appropriate inflammation is critical for host defense; however, an overactive response is detrimental to the host. Thus, inflammation must be tightly regulated. The molecular mechanisms underlying the tight regulation of inflammation remain largely unknown. Ecotropic viral integration site 1 (EVI1), a proto-oncogene and zinc finger transcription factor, plays important roles in normal development and leukemogenesis. However, its role in regulating NF-κB-dependent inflammation remains unknown. In this article, we show that EVI1 negatively regulates nontypeable Haemophilus influenzae- and TNF-α-induced NF-κB-dependent inflammation in vitro and in vivo. EVI1 directly binds to the NF-κB p65 subunit and inhibits its acetylation at lysine 310, thereby inhibiting its DNA-binding activity. Moreover, expression of EVI1 itself is induced by nontypeable Haemophilus influenzae and TNF-α in an NF-κB-dependent manner, thereby unveiling a novel inducible negative feedback loop to tightly control NF-κB-dependent inflammation. Thus, our study provides important insights into the novel role for EVI1 in negatively regulating NF-κB-dependent inflammation, and it may also shed light on the future development of novel anti-inflammatory strategies."xsd:string |
| http://purl.uniprot.org/citations/22581859 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1103527"xsd:string |
| http://purl.uniprot.org/citations/22581859 | http://purl.uniprot.org/core/author | "Brown S.D."xsd:string |
| http://purl.uniprot.org/citations/22581859 | http://purl.uniprot.org/core/author | "Huang Y."xsd:string |
| http://purl.uniprot.org/citations/22581859 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/22581859 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/22581859 | http://purl.uniprot.org/core/author | "Xu H."xsd:string |
| http://purl.uniprot.org/citations/22581859 | http://purl.uniprot.org/core/author | "Xu X."xsd:string |
| http://purl.uniprot.org/citations/22581859 | http://purl.uniprot.org/core/author | "Yan C."xsd:string |
| http://purl.uniprot.org/citations/22581859 | http://purl.uniprot.org/core/author | "Lim J.H."xsd:string |
| http://purl.uniprot.org/citations/22581859 | http://purl.uniprot.org/core/author | "Lee B.C."xsd:string |
| http://purl.uniprot.org/citations/22581859 | http://purl.uniprot.org/core/author | "Li J.D."xsd:string |
| http://purl.uniprot.org/citations/22581859 | http://purl.uniprot.org/core/author | "Pang J."xsd:string |
| http://purl.uniprot.org/citations/22581859 | http://purl.uniprot.org/core/author | "Woo C.H."xsd:string |
| http://purl.uniprot.org/citations/22581859 | http://purl.uniprot.org/core/author | "Cheeseman M.T."xsd:string |
| http://purl.uniprot.org/citations/22581859 | http://purl.uniprot.org/core/author | "Steere R.R."xsd:string |
| http://purl.uniprot.org/citations/22581859 | http://purl.uniprot.org/core/author | "Konduru A.S."xsd:string |
| http://purl.uniprot.org/citations/22581859 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22581859 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/22581859 | http://purl.uniprot.org/core/pages | "6371-6380"xsd:string |
| http://purl.uniprot.org/citations/22581859 | http://purl.uniprot.org/core/title | "EVI1 acts as an inducible negative-feedback regulator of NF-kappaB by inhibiting p65 acetylation."xsd:string |
| http://purl.uniprot.org/citations/22581859 | http://purl.uniprot.org/core/volume | "188"xsd:string |
| http://purl.uniprot.org/citations/22581859 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22581859 |
| http://purl.uniprot.org/citations/22581859 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22581859 |