| http://purl.uniprot.org/citations/22585573 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22585573 | http://www.w3.org/2000/01/rdf-schema#comment | "Acute graft-versus-host disease (GvHD) is a serious complication of allogeneic hematopoietic cell transplantation (allo-HCT) that results from donor allogeneic T cell attack on host tissues. Based on previous work implicating immune cell-derived C3a and C5a as regulators of T cell immunity, we examined the effects of locally produced C3a and C5a on murine T cell-mediated GvHD. We found that total body irradiation, a conditioning regimen required to permit engraftment of allo-HCT, caused upregulation and activation of alternative pathway complement components by recipient APCs. Allo-HCT with decay accelerating factor-null (Daf1(-/-)) host BM and Daf1(-/-) donor lymphocytes led to exacerbated GvHD outcome and resulted in splenic and organ-infiltrating T cell expansion. T cells deficient in C3a receptor (C3aR) and/or C5a receptor (C5aR) responded weakly in allogeneic hosts and exhibited limited ability to induce GvHD. Using a clinically relevant treatment strategy, we showed that pharmacological C5aR blockade reduced GvHD morbidity. Our data mechanistically link APC-derived complement to T cell-mediated GvHD and support complement inhibition as a therapeutic strategy for GvHD in humans."xsd:string |
| http://purl.uniprot.org/citations/22585573 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci61019"xsd:string |
| http://purl.uniprot.org/citations/22585573 | http://purl.uniprot.org/core/author | "Heeger P.S."xsd:string |
| http://purl.uniprot.org/citations/22585573 | http://purl.uniprot.org/core/author | "Paz-Artal E."xsd:string |
| http://purl.uniprot.org/citations/22585573 | http://purl.uniprot.org/core/author | "Medof M.E."xsd:string |
| http://purl.uniprot.org/citations/22585573 | http://purl.uniprot.org/core/author | "Merad M."xsd:string |
| http://purl.uniprot.org/citations/22585573 | http://purl.uniprot.org/core/author | "Hashimoto D."xsd:string |
| http://purl.uniprot.org/citations/22585573 | http://purl.uniprot.org/core/author | "Greter M."xsd:string |
| http://purl.uniprot.org/citations/22585573 | http://purl.uniprot.org/core/author | "Kwan W.H."xsd:string |
| http://purl.uniprot.org/citations/22585573 | http://purl.uniprot.org/core/author | "Ostrow K."xsd:string |
| http://purl.uniprot.org/citations/22585573 | http://purl.uniprot.org/core/author | "Raedler H."xsd:string |
| http://purl.uniprot.org/citations/22585573 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22585573 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/22585573 | http://purl.uniprot.org/core/pages | "2234-2238"xsd:string |
| http://purl.uniprot.org/citations/22585573 | http://purl.uniprot.org/core/title | "Antigen-presenting cell-derived complement modulates graft-versus-host disease."xsd:string |
| http://purl.uniprot.org/citations/22585573 | http://purl.uniprot.org/core/volume | "122"xsd:string |
| http://purl.uniprot.org/citations/22585573 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22585573 |
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