| http://purl.uniprot.org/citations/22588719 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22588719 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22588719 | http://www.w3.org/2000/01/rdf-schema#comment | "Sphingolipids are potent lipid second messengers that regulate cell differentiation, migration, survival, and secretion, and alterations in sphingolipid signaling have been implicated in a variety of diseases. However, how sphingolipid levels are regulated, particularly in the nervous system, remains poorly understood. Here, we show that the generation of sphingosine-1-phosphate by sphingosine kinase (SphK) promotes neurotransmitter release. Electrophysiological, imaging, and behavioral analyses of Caenorhabditis elegans mutants lacking sphingosine kinase sphk-1 indicate that neuronal development is normal, but there is a significant defect in neurotransmitter release from neuromuscular junctions. SPHK-1 localizes to discrete, nonvesicular regions within presynaptic terminals, and this localization is critical for synaptic function. Muscarinic agonists cause a rapid increase in presynaptic SPHK-1 abundance, whereas reduction of endogenous acetylcholine production results in a rapid decrease in presynaptic SPHK-1 abundance. Muscarinic regulation of presynaptic SPHK-1 abundance is mediated by a conserved presynaptic signaling pathway composed of the muscarinic acetylcholine receptor GAR-3, the heterotrimeric G protein Gαq, and its effector, Trio RhoGEF. SPHK-1 activity is required for the effects of muscarinic signaling on synaptic transmission. This study shows that SPHK-1 promotes neurotransmitter release in vivo and identifies a novel muscarinic pathway that regulates SphK abundance at presynaptic terminals."xsd:string |
| http://purl.uniprot.org/citations/22588719 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.188003.112"xsd:string |
| http://purl.uniprot.org/citations/22588719 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.188003.112"xsd:string |
| http://purl.uniprot.org/citations/22588719 | http://purl.uniprot.org/core/author | "Hu Z."xsd:string |
| http://purl.uniprot.org/citations/22588719 | http://purl.uniprot.org/core/author | "Hu Z."xsd:string |
| http://purl.uniprot.org/citations/22588719 | http://purl.uniprot.org/core/author | "Sieburth D."xsd:string |
| http://purl.uniprot.org/citations/22588719 | http://purl.uniprot.org/core/author | "Sieburth D."xsd:string |
| http://purl.uniprot.org/citations/22588719 | http://purl.uniprot.org/core/author | "Chan J.P."xsd:string |
| http://purl.uniprot.org/citations/22588719 | http://purl.uniprot.org/core/author | "Chan J.P."xsd:string |
| http://purl.uniprot.org/citations/22588719 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22588719 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22588719 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/22588719 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/22588719 | http://purl.uniprot.org/core/pages | "1070-1085"xsd:string |
| http://purl.uniprot.org/citations/22588719 | http://purl.uniprot.org/core/pages | "1070-1085"xsd:string |
| http://purl.uniprot.org/citations/22588719 | http://purl.uniprot.org/core/title | "Recruitment of sphingosine kinase to presynaptic terminals by a conserved muscarinic signaling pathway promotes neurotransmitter release."xsd:string |
| http://purl.uniprot.org/citations/22588719 | http://purl.uniprot.org/core/title | "Recruitment of sphingosine kinase to presynaptic terminals by a conserved muscarinic signaling pathway promotes neurotransmitter release."xsd:string |
| http://purl.uniprot.org/citations/22588719 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/22588719 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/22588719 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22588719 |
| http://purl.uniprot.org/citations/22588719 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22588719 |
| http://purl.uniprot.org/citations/22588719 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22588719 |
| http://purl.uniprot.org/citations/22588719 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22588719 |