| http://purl.uniprot.org/citations/22589474 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22589474 | http://www.w3.org/2000/01/rdf-schema#comment | "There has been recent controversy as to whether platelet α-granules represent a single granule population or are composed of different subpopulations that serve discrete functions. To address this question, we evaluated the localization of vesicle-associated membrane proteins (VAMPs) in spread platelets to determine whether platelets actively sort a specific subpopulation of α-granules to the periphery during spreading. Immunofluorescence microscopy demonstrated that granules expressing VAMP-3 and VAMP-8 localized to the central granulomere of spread platelets along with the granule cargos von Willebrand factor and serotonin. In contrast, α-granules expressing VAMP-7 translocated to the periphery of spread platelets along with the granule cargos TIMP2 and VEFG. Time-lapse microscopy demonstrated that α-granules expressing VAMP-7 actively moved from the granulomere to the periphery during spreading. Platelets from a patient with gray platelet syndrome lacked α-granules and demonstrated only minimal spreading. Similarly, spreading was impaired in platelets obtained from Unc13d(Jinx) mice, which are deficient in Munc13-4 and have an exocytosis defect. These studies identify a new α-granule subtype expressing VAMP-7 that moves to the periphery during spreading, supporting the premise that α-granules are heterogeneous and demonstrating that granule exocytosis is required for platelet spreading."xsd:string |
| http://purl.uniprot.org/citations/22589474 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2011-10-389247"xsd:string |
| http://purl.uniprot.org/citations/22589474 | http://purl.uniprot.org/core/author | "Michelson A.D."xsd:string |
| http://purl.uniprot.org/citations/22589474 | http://purl.uniprot.org/core/author | "Flaumenhaft R."xsd:string |
| http://purl.uniprot.org/citations/22589474 | http://purl.uniprot.org/core/author | "Peters C.G."xsd:string |
| http://purl.uniprot.org/citations/22589474 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22589474 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/22589474 | http://purl.uniprot.org/core/pages | "199-206"xsd:string |
| http://purl.uniprot.org/citations/22589474 | http://purl.uniprot.org/core/title | "Granule exocytosis is required for platelet spreading: differential sorting of alpha-granules expressing VAMP-7."xsd:string |
| http://purl.uniprot.org/citations/22589474 | http://purl.uniprot.org/core/volume | "120"xsd:string |
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