| http://purl.uniprot.org/citations/22589746 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22589746 | http://www.w3.org/2000/01/rdf-schema#comment | "PRDM family members are transcriptional regulators involved in tissue specific differentiation. PRDM5 has been reported to predominantly repress transcription, but a characterization of its molecular functions in a relevant biological context is lacking. We demonstrate here that Prdm5 is highly expressed in developing bones; and, by genome-wide mapping of Prdm5 occupancy in pre-osteoblastic cells, we uncover a novel and unique role for Prdm5 in targeting all mouse collagen genes as well as several SLRP proteoglycan genes. In particular, we show that Prdm5 controls both Collagen I transcription and fibrillogenesis by binding inside the Col1a1 gene body and maintaining RNA polymerase II occupancy. In vivo, Prdm5 loss results in delayed ossification involving a pronounced impairment in the assembly of fibrillar collagens. Collectively, our results define a novel role for Prdm5 in sustaining the transcriptional program necessary to the proper assembly of osteoblastic extracellular matrix."xsd:string |
| http://purl.uniprot.org/citations/22589746 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1002711"xsd:string |
| http://purl.uniprot.org/citations/22589746 | http://purl.uniprot.org/core/author | "Fuchs H."xsd:string |
| http://purl.uniprot.org/citations/22589746 | http://purl.uniprot.org/core/author | "Rappsilber J."xsd:string |
| http://purl.uniprot.org/citations/22589746 | http://purl.uniprot.org/core/author | "Lund A.H."xsd:string |
| http://purl.uniprot.org/citations/22589746 | http://purl.uniprot.org/core/author | "Jensen K.T."xsd:string |
| http://purl.uniprot.org/citations/22589746 | http://purl.uniprot.org/core/author | "Vortkamp A."xsd:string |
| http://purl.uniprot.org/citations/22589746 | http://purl.uniprot.org/core/author | "Wuelling M."xsd:string |
| http://purl.uniprot.org/citations/22589746 | http://purl.uniprot.org/core/author | "Carrara M."xsd:string |
| http://purl.uniprot.org/citations/22589746 | http://purl.uniprot.org/core/author | "Calogero R.A."xsd:string |
| http://purl.uniprot.org/citations/22589746 | http://purl.uniprot.org/core/author | "Gailus-Durner V."xsd:string |
| http://purl.uniprot.org/citations/22589746 | http://purl.uniprot.org/core/author | "Couchman J.R."xsd:string |
| http://purl.uniprot.org/citations/22589746 | http://purl.uniprot.org/core/author | "Multhaupt H.A."xsd:string |
| http://purl.uniprot.org/citations/22589746 | http://purl.uniprot.org/core/author | "Hrabe de Angelis M."xsd:string |
| http://purl.uniprot.org/citations/22589746 | http://purl.uniprot.org/core/author | "Hans W."xsd:string |
| http://purl.uniprot.org/citations/22589746 | http://purl.uniprot.org/core/author | "Fog C.K."xsd:string |
| http://purl.uniprot.org/citations/22589746 | http://purl.uniprot.org/core/author | "Galli G.G."xsd:string |
| http://purl.uniprot.org/citations/22589746 | http://purl.uniprot.org/core/author | "Coulton L."xsd:string |
| http://purl.uniprot.org/citations/22589746 | http://purl.uniprot.org/core/author | "Honnens de Lichtenberg K."xsd:string |
| http://purl.uniprot.org/citations/22589746 | http://purl.uniprot.org/core/author | "Mentz B."xsd:string |
| http://purl.uniprot.org/citations/22589746 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22589746 | http://purl.uniprot.org/core/name | "PLoS Genet"xsd:string |
| http://purl.uniprot.org/citations/22589746 | http://purl.uniprot.org/core/pages | "e1002711"xsd:string |
| http://purl.uniprot.org/citations/22589746 | http://purl.uniprot.org/core/title | "Prdm5 regulates collagen gene transcription by association with RNA polymerase II in developing bone."xsd:string |