| http://purl.uniprot.org/citations/22595515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22595515 | http://www.w3.org/2000/01/rdf-schema#comment | "Myoblast fusion is a key process in multinucleated muscle formation. Prior to fusion, myoblasts recognize and adhere to each other with the aid of cell-adhesion proteins integrated into the membrane. Their intracellular domains participate in signal transduction by binding to cytoplasmic proteins. Here we identified the calcium-dependent cell-adhesion protein N-cadherin as the binding partner of the guanine-nucleotide exchange factor Schizo/Loner in Drosophila melanogaster. N-cadherin was expressed in founder cells and fusion-competent myoblasts of Drosophila during the first fusion phase. Our genetic analyses demonstrated that the myoblast fusion defect of schizo/loner mutants is rescued in part by the loss-of-function mutation of N-cadherin, which suggests that Schizo/Loner is a negative regulator of N-cadherin. Based on our findings, we propose a model where N-cadherin must be removed from the myoblast membrane to induce a protein-free zone at the cell-cell contact point to permit fusion."xsd:string |
| http://purl.uniprot.org/citations/22595515 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2012.04.031"xsd:string |
| http://purl.uniprot.org/citations/22595515 | http://purl.uniprot.org/core/author | "Beck L."xsd:string |
| http://purl.uniprot.org/citations/22595515 | http://purl.uniprot.org/core/author | "Onel S.F."xsd:string |
| http://purl.uniprot.org/citations/22595515 | http://purl.uniprot.org/core/author | "Dottermusch-Heidel C."xsd:string |
| http://purl.uniprot.org/citations/22595515 | http://purl.uniprot.org/core/author | "Groth V."xsd:string |
| http://purl.uniprot.org/citations/22595515 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22595515 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/22595515 | http://purl.uniprot.org/core/pages | "18-27"xsd:string |
| http://purl.uniprot.org/citations/22595515 | http://purl.uniprot.org/core/title | "The Arf-GEF Schizo/Loner regulates N-cadherin to induce fusion competence of Drosophila myoblasts."xsd:string |
| http://purl.uniprot.org/citations/22595515 | http://purl.uniprot.org/core/volume | "368"xsd:string |
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| http://purl.uniprot.org/citations/22595515 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22595515 |
| http://purl.uniprot.org/uniprot/P35220#attribution-F0C3B2BCFAC10DC4A0AC7CABC1041315 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22595515 |
| http://purl.uniprot.org/uniprot/Q7KTX2#attribution-8D0386168866C829A9944085D19910F0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22595515 |
| http://purl.uniprot.org/uniprot/Q7KTX2#attribution-F0C3B2BCFAC10DC4A0AC7CABC1041315 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22595515 |
| http://purl.uniprot.org/uniprot/Q6U9V3#attribution-8D0386168866C829A9944085D19910F0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22595515 |
| http://purl.uniprot.org/uniprot/Q6U9V3#attribution-F0C3B2BCFAC10DC4A0AC7CABC1041315 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22595515 |
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| http://purl.uniprot.org/uniprot/Q9VP80#attribution-F0C3B2BCFAC10DC4A0AC7CABC1041315 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22595515 |
| http://purl.uniprot.org/uniprot/E1JI59#attribution-8D0386168866C829A9944085D19910F0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22595515 |
| http://purl.uniprot.org/uniprot/E1JI59#attribution-F0C3B2BCFAC10DC4A0AC7CABC1041315 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22595515 |
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| http://purl.uniprot.org/uniprot/Q5U112#attribution-F0C3B2BCFAC10DC4A0AC7CABC1041315 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22595515 |