| http://purl.uniprot.org/citations/22595670 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22595670 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22595670 | http://www.w3.org/2000/01/rdf-schema#comment | "Rab GTPases define the vesicle trafficking pathways underpinning cell polarization and migration. Here, we find that Rab4, Rab11, and Rab14 and the candidate Rab GDP-GTP exchange factors (GEFs) FAM116A and AVL9 are required for cell migration. Rab14 and its GEF FAM116A localize to and act on an intermediate compartment of the transferrin-recycling pathway prior to Rab11 and after Rab5 and Rab4. This Rab14 intermediate recycling compartment has specific functions in migrating cells discrete from early and recycling endosomes. Rab14-depleted cells show increased N-cadherin levels at junctional complexes and cannot resolve cell-cell junctions. This is due to decreased shedding of cell-surface N-cadherin by the ADAM family protease ADAM10/Kuzbanian. In FAM116A- and Rab14-depleted cells, ADAM10 accumulates in a transferrin-positive endocytic compartment, and the cell-surface level of ADAM10 is correspondingly reduced. FAM116 and Rab14 therefore define an endocytic recycling pathway needed for ADAM protease trafficking and regulation of cell-cell junctions."xsd:string |
| http://purl.uniprot.org/citations/22595670 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2012.04.010"xsd:string |
| http://purl.uniprot.org/citations/22595670 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2012.04.010"xsd:string |
| http://purl.uniprot.org/citations/22595670 | http://purl.uniprot.org/core/author | "Rigden D.J."xsd:string |
| http://purl.uniprot.org/citations/22595670 | http://purl.uniprot.org/core/author | "Rigden D.J."xsd:string |
| http://purl.uniprot.org/citations/22595670 | http://purl.uniprot.org/core/author | "Barr F.A."xsd:string |
| http://purl.uniprot.org/citations/22595670 | http://purl.uniprot.org/core/author | "Barr F.A."xsd:string |
| http://purl.uniprot.org/citations/22595670 | http://purl.uniprot.org/core/author | "Yoshimura S."xsd:string |
| http://purl.uniprot.org/citations/22595670 | http://purl.uniprot.org/core/author | "Yoshimura S."xsd:string |
| http://purl.uniprot.org/citations/22595670 | http://purl.uniprot.org/core/author | "Langemeyer L."xsd:string |
| http://purl.uniprot.org/citations/22595670 | http://purl.uniprot.org/core/author | "Langemeyer L."xsd:string |
| http://purl.uniprot.org/citations/22595670 | http://purl.uniprot.org/core/author | "Gerondopoulos A."xsd:string |
| http://purl.uniprot.org/citations/22595670 | http://purl.uniprot.org/core/author | "Gerondopoulos A."xsd:string |
| http://purl.uniprot.org/citations/22595670 | http://purl.uniprot.org/core/author | "Linford A."xsd:string |
| http://purl.uniprot.org/citations/22595670 | http://purl.uniprot.org/core/author | "Linford A."xsd:string |
| http://purl.uniprot.org/citations/22595670 | http://purl.uniprot.org/core/author | "Nunes Bastos R."xsd:string |
| http://purl.uniprot.org/citations/22595670 | http://purl.uniprot.org/core/author | "Nunes Bastos R."xsd:string |
| http://purl.uniprot.org/citations/22595670 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22595670 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22595670 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/22595670 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/22595670 | http://purl.uniprot.org/core/pages | "952-966"xsd:string |
| http://purl.uniprot.org/citations/22595670 | http://purl.uniprot.org/core/pages | "952-966"xsd:string |