| http://purl.uniprot.org/citations/22610972 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22610972 | http://www.w3.org/2000/01/rdf-schema#comment | "UnlabelledDeregulation of cellular-signaling pathways by the inactivation of tumor-suppressor genes is one of the major causes of hepatocellular carcinoma (HCC). In this study, we identified Tax1 binding protein 2 (TAX1BP2) as a novel tumor-suppressor gene in HCC. TAX1BP2 transcript was frequently underexpressed (42.2% with T/NT <0.5; P < 0.03) in HCCs, and underexpression of TAX1BP2 was associated with poorer overall survival rates in patients after surgical resection. An effector domain (ED) for TAX1BP2 tumor-suppressor activity was mapped to the amino-acid residues 267-756. Transient or stable expression of either full-length or ED of TAX1BP2 significantly suppressed HCC cell tumorigenicity through the activation of the p38/p53/p21 pathway. In contrast, silencing of TAX1BP2 by short interfering RNA remarkably suppressed the activation of the p38/p53/p21 pathway. Finally, phosphorylation of TAX1BP2 at serine-763 by cyclin-dependent kinase (CDK)2 abolished the TAX1BP2-mediated p38 activation and tumor-suppressive activity, indicating that TAX1BP2 can adapt CDK2 signaling to the p38/p53/p21 pathway.ConclusionTaken together, our data provide the first evidence that TAX1BP2 is a CDK2-regulated tumor-suppressor gene in HCC and is a novel activator of the p38/p53/p21 pathway."xsd:string |
| http://purl.uniprot.org/citations/22610972 | http://purl.org/dc/terms/identifier | "doi:10.1002/hep.25851"xsd:string |
| http://purl.uniprot.org/citations/22610972 | http://purl.uniprot.org/core/author | "Lee J.M."xsd:string |
| http://purl.uniprot.org/citations/22610972 | http://purl.uniprot.org/core/author | "Jin D.Y."xsd:string |
| http://purl.uniprot.org/citations/22610972 | http://purl.uniprot.org/core/author | "Zhou Y."xsd:string |
| http://purl.uniprot.org/citations/22610972 | http://purl.uniprot.org/core/author | "Wong L.L."xsd:string |
| http://purl.uniprot.org/citations/22610972 | http://purl.uniprot.org/core/author | "Lai W.L."xsd:string |
| http://purl.uniprot.org/citations/22610972 | http://purl.uniprot.org/core/author | "Ng I.O."xsd:string |
| http://purl.uniprot.org/citations/22610972 | http://purl.uniprot.org/core/author | "Ching Y.P."xsd:string |
| http://purl.uniprot.org/citations/22610972 | http://purl.uniprot.org/core/author | "Leong V.Y."xsd:string |
| http://purl.uniprot.org/citations/22610972 | http://purl.uniprot.org/core/author | "Hung W.Y."xsd:string |
| http://purl.uniprot.org/citations/22610972 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22610972 | http://purl.uniprot.org/core/name | "Hepatology"xsd:string |
| http://purl.uniprot.org/citations/22610972 | http://purl.uniprot.org/core/pages | "1770-1781"xsd:string |
| http://purl.uniprot.org/citations/22610972 | http://purl.uniprot.org/core/title | "The centrosomal protein Tax1 binding protein 2 is a novel tumor suppressor in hepatocellular carcinoma regulated by cyclin-dependent kinase 2."xsd:string |
| http://purl.uniprot.org/citations/22610972 | http://purl.uniprot.org/core/volume | "56"xsd:string |
| http://purl.uniprot.org/citations/22610972 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22610972 |
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