| http://purl.uniprot.org/citations/22611253 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22611253 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22611253 | http://www.w3.org/2000/01/rdf-schema#comment | "Elderly patients often suffer from multiple age-related diseases. Here we show that the expression of DJ-1, an antioxidant protein with reduced expression in the central nervous system of patients with Parkinson's disease, is reduced in pancreatic islets of patients with type 2 diabetes mellitus (T2DM). In contrast, under non-diabetic conditions, DJ-1 expression increases in mouse and human islets during aging. In mouse islets, we show that DJ-1 prevents an increase in reactive oxygen species levels as the mice age. This antioxidant function preserves mitochondrial integrity and physiology, prerequisites for glucose-stimulated insulin secretion. Accordingly, DJ-1-deficient mice develop glucose intolerance and reduced β cell area as they age or gain weight. Our data suggest that DJ-1 is more generally involved in age- and lifestyle-related human diseases and show for the first time that DJ-1 plays a key role in glucose homeostasis and might serve as a novel drug target for T2DM."xsd:string |
| http://purl.uniprot.org/citations/22611253 | http://purl.org/dc/terms/identifier | "doi:10.1093/jmcb/mjs025"xsd:string |
| http://purl.uniprot.org/citations/22611253 | http://purl.org/dc/terms/identifier | "doi:10.1093/jmcb/mjs025"xsd:string |
| http://purl.uniprot.org/citations/22611253 | http://purl.uniprot.org/core/author | "Jain R."xsd:string |
| http://purl.uniprot.org/citations/22611253 | http://purl.uniprot.org/core/author | "Jain R."xsd:string |
| http://purl.uniprot.org/citations/22611253 | http://purl.uniprot.org/core/author | "Jain D."xsd:string |
| http://purl.uniprot.org/citations/22611253 | http://purl.uniprot.org/core/author | "Jain D."xsd:string |
| http://purl.uniprot.org/citations/22611253 | http://purl.uniprot.org/core/author | "Bugliani M."xsd:string |
| http://purl.uniprot.org/citations/22611253 | http://purl.uniprot.org/core/author | "Bugliani M."xsd:string |
| http://purl.uniprot.org/citations/22611253 | http://purl.uniprot.org/core/author | "Marchetti P."xsd:string |
| http://purl.uniprot.org/citations/22611253 | http://purl.uniprot.org/core/author | "Marchetti P."xsd:string |
| http://purl.uniprot.org/citations/22611253 | http://purl.uniprot.org/core/author | "Piemonti L."xsd:string |
| http://purl.uniprot.org/citations/22611253 | http://purl.uniprot.org/core/author | "Piemonti L."xsd:string |
| http://purl.uniprot.org/citations/22611253 | http://purl.uniprot.org/core/author | "Lammert E."xsd:string |
| http://purl.uniprot.org/citations/22611253 | http://purl.uniprot.org/core/author | "Lammert E."xsd:string |
| http://purl.uniprot.org/citations/22611253 | http://purl.uniprot.org/core/author | "Eberhard D."xsd:string |
| http://purl.uniprot.org/citations/22611253 | http://purl.uniprot.org/core/author | "Eberhard D."xsd:string |
| http://purl.uniprot.org/citations/22611253 | http://purl.uniprot.org/core/author | "Eglinger J."xsd:string |
| http://purl.uniprot.org/citations/22611253 | http://purl.uniprot.org/core/author | "Eglinger J."xsd:string |
| http://purl.uniprot.org/citations/22611253 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22611253 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22611253 | http://purl.uniprot.org/core/name | "J. Mol. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/22611253 | http://purl.uniprot.org/core/name | "J. Mol. Cell Biol."xsd:string |