| http://purl.uniprot.org/citations/22613798 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22613798 | http://www.w3.org/2000/01/rdf-schema#comment | "Natural killer (NK) cells play a critical role in early host defense to infected and transformed cells. Here, we show that mice deficient in Eri1, a conserved 3'-to-5' exoribonuclease that represses RNA interference, have a cell-intrinsic defect in NK-cell development and maturation. Eri1(-/-) NK cells displayed delayed acquisition of Ly49 receptors in the bone marrow (BM) and a selective reduction in Ly49D and Ly49H activating receptors in the periphery. Eri1 was required for immune-mediated control of mouse CMV (MCMV) infection. Ly49H(+) NK cells deficient in Eri1 failed to expand efficiently during MCMV infection, and virus-specific responses were also diminished among Eri1(-/-) T cells. We identified miRNAs as the major endogenous small RNA target of Eri1 in mouse lymphocytes. Both NK and T cells deficient in Eri1 displayed a global, sequence-independent increase in miRNA abundance. Ectopic Eri1 expression rescued defective miRNA expression in mature Eri1(-/-) T cells. Thus, mouse Eri1 regulates miRNA homeostasis in lymphocytes and is required for normal NK-cell development and antiviral immunity."xsd:string |
| http://purl.uniprot.org/citations/22613798 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2011-11-394072"xsd:string |
| http://purl.uniprot.org/citations/22613798 | http://purl.uniprot.org/core/author | "Lanier L.L."xsd:string |
| http://purl.uniprot.org/citations/22613798 | http://purl.uniprot.org/core/author | "Heissmeyer V."xsd:string |
| http://purl.uniprot.org/citations/22613798 | http://purl.uniprot.org/core/author | "Babiarz J.E."xsd:string |
| http://purl.uniprot.org/citations/22613798 | http://purl.uniprot.org/core/author | "Ansel K.M."xsd:string |
| http://purl.uniprot.org/citations/22613798 | http://purl.uniprot.org/core/author | "Rajaram M."xsd:string |
| http://purl.uniprot.org/citations/22613798 | http://purl.uniprot.org/core/author | "Abdul-Wajid S."xsd:string |
| http://purl.uniprot.org/citations/22613798 | http://purl.uniprot.org/core/author | "Woodruff P."xsd:string |
| http://purl.uniprot.org/citations/22613798 | http://purl.uniprot.org/core/author | "Thomas M.F."xsd:string |
| http://purl.uniprot.org/citations/22613798 | http://purl.uniprot.org/core/author | "Panduro M."xsd:string |
| http://purl.uniprot.org/citations/22613798 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22613798 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/22613798 | http://purl.uniprot.org/core/pages | "130-142"xsd:string |
| http://purl.uniprot.org/citations/22613798 | http://purl.uniprot.org/core/title | "Eri1 regulates microRNA homeostasis and mouse lymphocyte development and antiviral function."xsd:string |
| http://purl.uniprot.org/citations/22613798 | http://purl.uniprot.org/core/volume | "120"xsd:string |
| http://purl.uniprot.org/citations/22613798 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22613798 |
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| http://purl.uniprot.org/uniprot/#_P34902-mappedCitation-22613798 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22613798 |
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