| http://purl.uniprot.org/citations/22614125 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22614125 | http://www.w3.org/2000/01/rdf-schema#comment | "Renal fibrosis is a common finding in progressive renal diseases. Matrix metalloproteinases (MMPs) are involved in epithelial-to-mesenchymal transition (EMT). We investigated the role of MMP-2 and the effect of inhibition of MMPs on the development of renal fibrosis. Renal fibrosis was induced in MMP-2 wild-type (MMP-2⁺/⁺) mice by unilateral ureteral obstruction (UUO). Renal histopathology, EMT-associated molecules, and activity of MMP-2 and MMP-9 were examined during the development of interstitial fibrosis. UUO-renal fibrosis was also induced in MMP-2 deficient (MMP-2⁻/⁻) and MMP-2⁺/⁺ mice treated with minocycline (inhibitor of MMPs). In MMP-2⁺/⁺ mice, MMP-2 and MMP-9 were expressed in damaged tubules, and their activities increased in a time-dependent manner after UUO. Interstitial fibrosis was noted at day 14, with deposition of types III and I collagens and expression of markers of mesenchymal cells (S100A4, vimentin, α-smooth muscle actin, and heat shock protein-47) in damaged tubular epithelial cells, together with F4/80+ macrophage infiltration. Fibrotic kidneys expressed EMT-associated molecules (ILK, TGF-β1, Smad, Wnt, β-catenin, and Snail). In contrast, the kidneys of MMP-2⁻/⁻ mice and minocycline-treated MMP-2⁺/⁺ mice showed amelioration of renal fibrosis with reduced expression of markers of mesenchymal cells in tubular epithelial cells, inhibition of upregulated EMT-associated molecules, and suppression of macrophage infiltration. The results suggested that MMP-2 have a pathogenic role in renal interstitial fibrosis, possibly through the induction of EMT and macrophage infiltration. Inhibition of MMPs may be beneficial therapeutically in renal fibrosis."xsd:string |
| http://purl.uniprot.org/citations/22614125 | http://purl.org/dc/terms/identifier | "doi:10.1038/labinvest.2012.68"xsd:string |
| http://purl.uniprot.org/citations/22614125 | http://purl.uniprot.org/core/author | "Kataoka M."xsd:string |
| http://purl.uniprot.org/citations/22614125 | http://purl.uniprot.org/core/author | "Kaneko T."xsd:string |
| http://purl.uniprot.org/citations/22614125 | http://purl.uniprot.org/core/author | "Masuda Y."xsd:string |
| http://purl.uniprot.org/citations/22614125 | http://purl.uniprot.org/core/author | "Shimizu A."xsd:string |
| http://purl.uniprot.org/citations/22614125 | http://purl.uniprot.org/core/author | "Fukuda Y."xsd:string |
| http://purl.uniprot.org/citations/22614125 | http://purl.uniprot.org/core/author | "Du X."xsd:string |
| http://purl.uniprot.org/citations/22614125 | http://purl.uniprot.org/core/author | "Arai T."xsd:string |
| http://purl.uniprot.org/citations/22614125 | http://purl.uniprot.org/core/author | "Iino Y."xsd:string |
| http://purl.uniprot.org/citations/22614125 | http://purl.uniprot.org/core/author | "Uchiyama M."xsd:string |
| http://purl.uniprot.org/citations/22614125 | http://purl.uniprot.org/core/author | "Kuwahara N."xsd:string |
| http://purl.uniprot.org/citations/22614125 | http://purl.uniprot.org/core/author | "Akimoto T."xsd:string |
| http://purl.uniprot.org/citations/22614125 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22614125 | http://purl.uniprot.org/core/name | "Lab Invest"xsd:string |
| http://purl.uniprot.org/citations/22614125 | http://purl.uniprot.org/core/pages | "1149-1160"xsd:string |
| http://purl.uniprot.org/citations/22614125 | http://purl.uniprot.org/core/title | "Involvement of matrix metalloproteinase-2 in the development of renal interstitial fibrosis in mouse obstructive nephropathy."xsd:string |
| http://purl.uniprot.org/citations/22614125 | http://purl.uniprot.org/core/volume | "92"xsd:string |
| http://purl.uniprot.org/citations/22614125 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22614125 |
| http://purl.uniprot.org/citations/22614125 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22614125 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GS88-mappedCitation-22614125 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22614125 |
| http://purl.uniprot.org/uniprot/#_Q3UG07-mappedCitation-22614125 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22614125 |
| http://purl.uniprot.org/uniprot/#_P33434-mappedCitation-22614125 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22614125 |
| http://purl.uniprot.org/uniprot/#_Q75UT7-mappedCitation-22614125 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22614125 |