| http://purl.uniprot.org/citations/22615807 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22615807 | http://www.w3.org/2000/01/rdf-schema#comment | "Sm-like (Lsm) proteins are ubiquitous and function in many aspects of RNA metabolism, including pre-mRNA splicing, nuclear RNA processing, mRNA decay and miRNA biogenesis. Here three crystal structures including Lsm3, Lsm4 and Lsm5/6/7 sub-complex from S. pombe are reported. These structures show that all the five individual Lsm subunits share a conserved Sm fold, and Lsm3, Lsm4, and Lsm5/6/7 form a heptamer, a trimer and a hexamer within the crystal lattice, respectively. Analytical ultracentrifugation indicates that Lsm3 and Lsm5/6/7 sub-complex exist in solution as a heptamer and a hexamer, respectively while Lsm4 undergoes a dynamic equilibrium between monomer and trimer in solution. RNA binding assays show that Lsm2/3 and Lsm5/6/7 bind to oligo(U) whereas no RNA binding is observed for Lsm3 and Lsm4. Analysis of the inter-subunit interactions in Lsm5/6/7 reveals the organization order among Lsm5, Lsm6 and Lsm7."xsd:string |
| http://purl.uniprot.org/citations/22615807 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0036768"xsd:string |
| http://purl.uniprot.org/citations/22615807 | http://purl.uniprot.org/core/author | "Jiang S."xsd:string |
| http://purl.uniprot.org/citations/22615807 | http://purl.uniprot.org/core/author | "Wu D."xsd:string |
| http://purl.uniprot.org/citations/22615807 | http://purl.uniprot.org/core/author | "Song H."xsd:string |
| http://purl.uniprot.org/citations/22615807 | http://purl.uniprot.org/core/author | "Bowler M.W."xsd:string |
| http://purl.uniprot.org/citations/22615807 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22615807 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/22615807 | http://purl.uniprot.org/core/pages | "e36768"xsd:string |
| http://purl.uniprot.org/citations/22615807 | http://purl.uniprot.org/core/title | "Crystal structures of Lsm3, Lsm4 and Lsm5/6/7 from Schizosaccharomyces pombe."xsd:string |
| http://purl.uniprot.org/citations/22615807 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/22615807 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22615807 |
| http://purl.uniprot.org/citations/22615807 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22615807 |
| http://purl.uniprot.org/uniprot/O42978#attribution-D6E9FD9C1DB35A650653FA6CEE608990 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22615807 |
| http://purl.uniprot.org/uniprot/Q9UUI1#attribution-D6E9FD9C1DB35A650653FA6CEE608990 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22615807 |
| http://purl.uniprot.org/uniprot/O74499#attribution-D6E9FD9C1DB35A650653FA6CEE608990 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22615807 |
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| http://purl.uniprot.org/uniprot/#_O74499-mappedCitation-22615807 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22615807 |
| http://purl.uniprot.org/uniprot/#_O14352-mappedCitation-22615807 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22615807 |
| http://purl.uniprot.org/uniprot/#_Q9UUI1-mappedCitation-22615807 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22615807 |
| http://purl.uniprot.org/uniprot/#_Q9Y7M4-mappedCitation-22615807 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22615807 |
| http://purl.uniprot.org/uniprot/O42978 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22615807 |
| http://purl.uniprot.org/uniprot/O14352 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22615807 |
| http://purl.uniprot.org/uniprot/Q9Y7M4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22615807 |