| http://purl.uniprot.org/citations/22622498 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22622498 | http://www.w3.org/2000/01/rdf-schema#comment | "The accumulation of plasma advanced oxidation protein products (AOPPs) is prevalent in chronic kidney disease. We previously showed that accumulation of AOPPs resulted in podocyte apoptosis and their deletion by a cascade of signaling events coupled with intracellular oxidative stress. The transmembrane receptor that specifically transmits the AOPPs' signals to elicit cellular activity, however, remains unknown. Using co-immunoprecipitation and immunofluorescence, we found that AOPPs colocalized and interacted with the receptor of advanced glycation end products (RAGE) on podocytes. Blocking RAGE by anti-RAGE immunoglobulin G or its silencing by siRNA significantly protected podocytes from AOPPs-induced apoptosis both in vitro and in vivo and ameliorated albuminuria in AOPPs-challenged mice. AOPPs-induced activation of nicotinamide adenine dinucleotide phosphate oxidase and the excessive generation of intracellular superoxide were largely inhibited by anti-RAGE immunoglobulin G or RAGE siRNA. Moreover, blockade of RAGE decreased the activation of the p53/Bax/caspase-dependent proapoptotic pathway induced by AOPPs. Thus, AOPPs interact with RAGE to induce podocyte apoptosis and this, in part, may contribute to the progression of chronic kidney disease."xsd:string |
| http://purl.uniprot.org/citations/22622498 | http://purl.org/dc/terms/identifier | "doi:10.1038/ki.2012.184"xsd:string |
| http://purl.uniprot.org/citations/22622498 | http://purl.uniprot.org/core/author | "Li A."xsd:string |
| http://purl.uniprot.org/citations/22622498 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/22622498 | http://purl.uniprot.org/core/author | "Miyata T."xsd:string |
| http://purl.uniprot.org/citations/22622498 | http://purl.uniprot.org/core/author | "Tian J."xsd:string |
| http://purl.uniprot.org/citations/22622498 | http://purl.uniprot.org/core/author | "Zhou Z."xsd:string |
| http://purl.uniprot.org/citations/22622498 | http://purl.uniprot.org/core/author | "Zhu P."xsd:string |
| http://purl.uniprot.org/citations/22622498 | http://purl.uniprot.org/core/author | "Xie C."xsd:string |
| http://purl.uniprot.org/citations/22622498 | http://purl.uniprot.org/core/author | "Zhou Q."xsd:string |
| http://purl.uniprot.org/citations/22622498 | http://purl.uniprot.org/core/author | "Cao W."xsd:string |
| http://purl.uniprot.org/citations/22622498 | http://purl.uniprot.org/core/author | "Zhou L.L."xsd:string |
| http://purl.uniprot.org/citations/22622498 | http://purl.uniprot.org/core/author | "Nie J."xsd:string |
| http://purl.uniprot.org/citations/22622498 | http://purl.uniprot.org/core/author | "Hou F.F."xsd:string |
| http://purl.uniprot.org/citations/22622498 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22622498 | http://purl.uniprot.org/core/name | "Kidney Int"xsd:string |
| http://purl.uniprot.org/citations/22622498 | http://purl.uniprot.org/core/pages | "759-770"xsd:string |
| http://purl.uniprot.org/citations/22622498 | http://purl.uniprot.org/core/title | "The receptor of advanced glycation end products plays a central role in advanced oxidation protein products-induced podocyte apoptosis."xsd:string |
| http://purl.uniprot.org/citations/22622498 | http://purl.uniprot.org/core/volume | "82"xsd:string |
| http://purl.uniprot.org/citations/22622498 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22622498 |
| http://purl.uniprot.org/citations/22622498 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22622498 |
| http://purl.uniprot.org/uniprot/#_F1ABR7-mappedCitation-22622498 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22622498 |
| http://purl.uniprot.org/uniprot/#_F1ABR8-mappedCitation-22622498 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22622498 |
| http://purl.uniprot.org/uniprot/#_F1ABR9-mappedCitation-22622498 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22622498 |