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http://purl.uniprot.org/citations/22625427http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22625427http://www.w3.org/2000/01/rdf-schema#comment"

Background

Zinc-alpha2-glycoprotein (AZGP1, ZAG) was recently demonstrated to be an important factor in tumor carcinogenesis. However, AZGP1 expression in hepatocellular carcinoma (HCC) and its significance remain largely unknown.

Methods

Quantitative real-time polymerase chain reaction (qRT-PCR) was applied to determine mRNA level of AZGP1 in 20 paired fresh HCC tissues. Clinical and pathological data of 246 HCC patients were collected. Tissue-microarray-based immunohistochemistry (IHC) was performed to examine AZGP1 expression in HCC samples. Relationship between AZGP1 expression and clinicopathological features was analyzed by Chi-square test, Kaplan-Meier analysis and Cox proportional hazards regression model.

Results

AZGP1 expression was significantly lower in 80.0% (16/20) of tumorous tissues than that in the corresponding adjacent nontumorous liver tissues (P < 0.001). Consistently, IHC data revealed that decreased expression of AZGP1 was present in 80.1% (197/246) of HCC patient tissues (P < 0.001). Furthermore, AZGP1 expression in HCC significantly associated with several clinicopathological parameters, including serum AFP level (P = 0.013), liver cirrhosis (P = 0.002) and tumor differentiation (P = 0.025). Moreover, HCC patients with high AZGP1 expression survived longer, with better overall survival (P = 0.006) and disease-free survival (P = 0.025). In addition, low AZGP1 expression associated with worse relapse-free survival (P = 0.046) and distant metastatic progression-free survival (P = 0.036).

Conclusion

AZGP1 was downregulated in HCC and could be served as a promising prognostic marker for HCC patients."xsd:string
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http://purl.uniprot.org/citations/22625427http://purl.uniprot.org/core/author"Huang Y."xsd:string
http://purl.uniprot.org/citations/22625427http://purl.uniprot.org/core/author"Li Y."xsd:string
http://purl.uniprot.org/citations/22625427http://purl.uniprot.org/core/author"Zhou X."xsd:string
http://purl.uniprot.org/citations/22625427http://purl.uniprot.org/core/author"Yi C."xsd:string
http://purl.uniprot.org/citations/22625427http://purl.uniprot.org/core/author"Liu L.L."xsd:string
http://purl.uniprot.org/citations/22625427http://purl.uniprot.org/core/author"Yun J.P."xsd:string
http://purl.uniprot.org/citations/22625427http://purl.uniprot.org/core/author"Zhang C.Z."xsd:string
http://purl.uniprot.org/citations/22625427http://purl.uniprot.org/core/author"Li L.Z."xsd:string
http://purl.uniprot.org/citations/22625427http://purl.uniprot.org/core/author"Xie G.B."xsd:string
http://purl.uniprot.org/citations/22625427http://purl.uniprot.org/core/author"Cai M.Y."xsd:string
http://purl.uniprot.org/citations/22625427http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/22625427http://purl.uniprot.org/core/name"J Transl Med"xsd:string
http://purl.uniprot.org/citations/22625427http://purl.uniprot.org/core/pages"106"xsd:string
http://purl.uniprot.org/citations/22625427http://purl.uniprot.org/core/title"Decreased expression of zinc-alpha2-glycoprotein in hepatocellular carcinoma associates with poor prognosis."xsd:string
http://purl.uniprot.org/citations/22625427http://purl.uniprot.org/core/volume"10"xsd:string
http://purl.uniprot.org/citations/22625427http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/22625427
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