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http://purl.uniprot.org/citations/22627368http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22627368http://www.w3.org/2000/01/rdf-schema#comment"

Background

Galectin-9 (Gal-9) is a member of the galectin family of lectins that exhibit binding affinity for β-galactosides. We found a T cell line-derived Gal-9 with novel eosinophil chemoattractant activity, but its role in eosinophilic inflammation of the lung is unknown. We evaluated the role of Gal-9 in Ascaris suum-induced eosinophilic lung inflammation in mice.

Methods

To evaluate the role of Gal-9 in Ascaris suum-induced eosinophilic lung inflammation, we developed a mouse model of eosinophilic pneumonia induced by the Ascaris suum antigen, and analyzed eosinophilic inflammation in Gal-9-deficient mice. The therapeutic effects of recombinant Gal-9 on lung inflammation were also examined in this mouse model. To evaluate lung inflammation, numbers of inflammatory cells and cytokine levels in the bronchoalveolar lavage fluid (BALF) were estimated by flow cytometry and enzyme-linked immunosorbent assay, respectively.

Results

The BALF of this mouse model of eosinophilic pneumonia induced by the Ascaris suum antigen contained increased numbers of inflammatory cells and elevated Gal-9 levels. Compared with wild-type mice, the BALF of Gal-9-deficient mice contained higher numbers of both eosinophils and T helper type 2 (Th2) cells. Th2 cytokines and eotaxin levels were also higher, and levels of CD4+CD25+Foxp3+ regulatory T cells were lower in Gal-9-deficient mice than in wild-type mice. Intranasal administration of recombinant Gal-9 prevented eosinophilic inflammation of the lung and upregulated the release of endogenous Gal-9.

Conclusions

Our findings suggest that Gal-9 negatively regulates Th2-mediated eosinophilic inflammation of the lung and that Foxp3+ regulatory T cells might be involved in suppressing allergic inflammation."xsd:string
http://purl.uniprot.org/citations/22627368http://purl.org/dc/terms/identifier"doi:10.1159/000337769"xsd:string
http://purl.uniprot.org/citations/22627368http://purl.uniprot.org/core/author"Oka M."xsd:string
http://purl.uniprot.org/citations/22627368http://purl.uniprot.org/core/author"Shimizu H."xsd:string
http://purl.uniprot.org/citations/22627368http://purl.uniprot.org/core/author"Katoh S."xsd:string
http://purl.uniprot.org/citations/22627368http://purl.uniprot.org/core/author"Niki T."xsd:string
http://purl.uniprot.org/citations/22627368http://purl.uniprot.org/core/author"Hirashima M."xsd:string
http://purl.uniprot.org/citations/22627368http://purl.uniprot.org/core/author"Oomizu S."xsd:string
http://purl.uniprot.org/citations/22627368http://purl.uniprot.org/core/author"Korenaga M."xsd:string
http://purl.uniprot.org/citations/22627368http://purl.uniprot.org/core/author"Obase Y."xsd:string
http://purl.uniprot.org/citations/22627368http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/22627368http://purl.uniprot.org/core/name"Int Arch Allergy Immunol 158 Suppl"xsd:string
http://purl.uniprot.org/citations/22627368http://purl.uniprot.org/core/pages"58-65"xsd:string
http://purl.uniprot.org/citations/22627368http://purl.uniprot.org/core/title"Possible regulatory role of galectin-9 on Ascaris suum-induced eosinophilic lung inflammation in mice."xsd:string
http://purl.uniprot.org/citations/22627368http://purl.uniprot.org/core/volume"1"xsd:string
http://purl.uniprot.org/citations/22627368http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/22627368
http://purl.uniprot.org/citations/22627368http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/22627368
http://purl.uniprot.org/uniprot/#_G3X9T7-mappedCitation-22627368http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22627368
http://purl.uniprot.org/uniprot/#_O08573-mappedCitation-22627368http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22627368
http://purl.uniprot.org/uniprot/O08573http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/22627368
http://purl.uniprot.org/uniprot/G3X9T7http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/22627368