| http://purl.uniprot.org/citations/22627768 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22627768 | http://www.w3.org/2000/01/rdf-schema#comment | "Pathologische anatomie leiden endothelium (PAL-E) antibody has been used for more than 20 years as a prototype marker for vascular endothelium. The elusive target of this antibody has been claimed to be plasmalemma vesicle-associated protein-1 (PV-1) and neuropilin-1 (NRP-1). Using immunofluorescence, we show that PAL-E, anti-PV-1, anti-NRP-1, and anti-CD31 antibodies show largely identical staining patterns in the vasculature of different tissues. However, PV-1-transfected cells only bind PAL-E and anti-PV-1 antibodies, whereas NRP-1 transfectants stain with anti-NRP-1 antibodies in flow cytometry. Using lysates from tissues and transfected cells, we further confirm that the molecule recognized by PAL-E and anti-PV-1 antibodies is not NRP-1 but PV-1. Nevertheless, coimmunoprecipitation studies unambiguously demonstrate that NRP-1 can form complexes with PV-1. This connects, for the first time, 2 molecules involved in leukocyte trafficking and angiogenesis, thereby opening interesting possibilities for future research in this field."xsd:string |
| http://purl.uniprot.org/citations/22627768 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2012-01-406876"xsd:string |
| http://purl.uniprot.org/citations/22627768 | http://purl.uniprot.org/core/author | "Salminen T."xsd:string |
| http://purl.uniprot.org/citations/22627768 | http://purl.uniprot.org/core/author | "Alitalo K."xsd:string |
| http://purl.uniprot.org/citations/22627768 | http://purl.uniprot.org/core/author | "Elima K."xsd:string |
| http://purl.uniprot.org/citations/22627768 | http://purl.uniprot.org/core/author | "Jalkanen S."xsd:string |
| http://purl.uniprot.org/citations/22627768 | http://purl.uniprot.org/core/author | "Salmi M."xsd:string |
| http://purl.uniprot.org/citations/22627768 | http://purl.uniprot.org/core/author | "Tvorogov D."xsd:string |
| http://purl.uniprot.org/citations/22627768 | http://purl.uniprot.org/core/author | "Keuschnigg J."xsd:string |
| http://purl.uniprot.org/citations/22627768 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22627768 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/22627768 | http://purl.uniprot.org/core/pages | "232-235"xsd:string |
| http://purl.uniprot.org/citations/22627768 | http://purl.uniprot.org/core/title | "PV-1 is recognized by the PAL-E antibody and forms complexes with NRP-1."xsd:string |
| http://purl.uniprot.org/citations/22627768 | http://purl.uniprot.org/core/volume | "120"xsd:string |
| http://purl.uniprot.org/citations/22627768 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22627768 |
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