| http://purl.uniprot.org/citations/22633274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22633274 | http://www.w3.org/2000/01/rdf-schema#comment | "In order to investigate the biomarkers associated with relapsing-remitting multiple sclerosis (RRMS), we analyzed 72 patients with RRMS and 65 healthy controls using proteome technology. Peptides in sera were purified using magnetic beads, and analyzed by matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry and ClinProTool software. Thirteen peptides were significantly different between patients with RRMS and healthy controls. Furthermore, a pattern of peaks was selected for genetic algorithm (GA), supervised neural network (SNN) and quick classifier (QC) model building. Among these three models, GA method was best with 93.49% of recognition capability and 82.66% of cross-validation and discriminated the proteomic spectra in patients with RRMS from healthy controls, with a sensitivity of 80% and a specificity of 91.3%. Meanwhile, the first peptide with m/z 2023.3 was identified as fragment of nucleolin protein. There is a possible relationship between the fragment peptide of nucleolin and the trigger of relapse in MS. Sera nucleolin may serve as a possible biomarker of RRMS."xsd:string |
| http://purl.uniprot.org/citations/22633274 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jneuroim.2012.05.002"xsd:string |
| http://purl.uniprot.org/citations/22633274 | http://purl.uniprot.org/core/author | "Dong H."xsd:string |
| http://purl.uniprot.org/citations/22633274 | http://purl.uniprot.org/core/author | "Jia J."xsd:string |
| http://purl.uniprot.org/citations/22633274 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/22633274 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/22633274 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/22633274 | http://purl.uniprot.org/core/author | "Qiao Y."xsd:string |
| http://purl.uniprot.org/citations/22633274 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/22633274 | http://purl.uniprot.org/core/author | "Yin L."xsd:string |
| http://purl.uniprot.org/citations/22633274 | http://purl.uniprot.org/core/author | "Xu E."xsd:string |
| http://purl.uniprot.org/citations/22633274 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22633274 | http://purl.uniprot.org/core/name | "J Neuroimmunol"xsd:string |
| http://purl.uniprot.org/citations/22633274 | http://purl.uniprot.org/core/pages | "71-76"xsd:string |
| http://purl.uniprot.org/citations/22633274 | http://purl.uniprot.org/core/title | "Decreased serum levels of nucleolin protein fragment, as analyzed by bead-based proteomic technology, in multiple sclerosis patients compared to controls."xsd:string |
| http://purl.uniprot.org/citations/22633274 | http://purl.uniprot.org/core/volume | "250"xsd:string |
| http://purl.uniprot.org/citations/22633274 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22633274 |
| http://purl.uniprot.org/citations/22633274 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22633274 |
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| http://purl.uniprot.org/uniprot/#_B3KTP9-mappedCitation-22633274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22633274 |
| http://purl.uniprot.org/uniprot/#_L8EAF1-mappedCitation-22633274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22633274 |
| http://purl.uniprot.org/uniprot/#_P19338-mappedCitation-22633274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22633274 |
| http://purl.uniprot.org/uniprot/#_Q6ZS99-mappedCitation-22633274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22633274 |
| http://purl.uniprot.org/uniprot/#_Q9BQ02-mappedCitation-22633274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22633274 |