| http://purl.uniprot.org/citations/22635104 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22635104 | http://www.w3.org/2000/01/rdf-schema#comment | "The p75 neurotrophin receptor (p75NTR) has been thought to play a critical role in amyloid-β peptide (Aβ)-mediated neurodegeneration and Aβ metabolism in Alzheimer's disease (AD) brains. Our previous report showed that membrane-associated p75NTR protein expression was significantly increased in the hippocampi of two different strains of transgenic AD mice and was associated with the age-dependent elevation of Aβ1-42 levels. Here, we provide evidence that the Aβ1-42 oligomers known as ADDLs (Aβ-derived diffusible ligands) induce p75NTR protein expression through insulin-like growth factor 1 receptor (IGF-1R) phosphorylation in SH-SY5Y human neuroblastoma cells. An in vivo microinjection study demonstrated that microinjected ADDLs increased the p75NTR protein expression by 1.4-fold in the ipsilateral hippocampus compared to the contralateral hippocampus. In addition, ADDLs microinjected into mouse hippocampi facilitated IGF-1R phosphorylation within 30 min and the co-administration of picropodophyllin, an IGF-1R kinase inhibitor, blocked ADDLs-induced p75NTR expression. We examined the possible involvement of IGF-1R in the increased p75NTR protein expression in the hippocampi of 6-month-old AβPPswe/PS1dE9 AD model mice that had accumulated significant amounts of Aβ1-42 and showed significantly higher p75NTR expression than age-matched wild-type mice. We found that IGF-1R phosphorylation in these transgenic mice was higher than that in the wild-type mice. These findings indicate that Aβ1-42 oligomers stimulate the p75NTR protein expression in the hippocampus through IGF-1R signaling. Thus, Aβ1-42 oligomers-mediated IGF-1R activation may trigger an increase in p75NTR protein expression in the hippocampus of AD brain during the early stages of disease development."xsd:string |
| http://purl.uniprot.org/citations/22635104 | http://purl.org/dc/terms/identifier | "doi:10.3233/jad-2012-120046"xsd:string |
| http://purl.uniprot.org/citations/22635104 | http://purl.uniprot.org/core/author | "Ito S."xsd:string |
| http://purl.uniprot.org/citations/22635104 | http://purl.uniprot.org/core/author | "Atkinson T."xsd:string |
| http://purl.uniprot.org/citations/22635104 | http://purl.uniprot.org/core/author | "Menard M."xsd:string |
| http://purl.uniprot.org/citations/22635104 | http://purl.uniprot.org/core/author | "Brown L."xsd:string |
| http://purl.uniprot.org/citations/22635104 | http://purl.uniprot.org/core/author | "Whitfield J."xsd:string |
| http://purl.uniprot.org/citations/22635104 | http://purl.uniprot.org/core/author | "Chakravarthy B."xsd:string |
| http://purl.uniprot.org/citations/22635104 | http://purl.uniprot.org/core/author | "Gaudet C."xsd:string |
| http://purl.uniprot.org/citations/22635104 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22635104 | http://purl.uniprot.org/core/name | "J Alzheimers Dis"xsd:string |
| http://purl.uniprot.org/citations/22635104 | http://purl.uniprot.org/core/pages | "493-506"xsd:string |
| http://purl.uniprot.org/citations/22635104 | http://purl.uniprot.org/core/title | "Involvement of insulin-like growth factor 1 receptor signaling in the amyloid-beta peptide oligomers-induced p75 neurotrophin receptor protein expression in mouse hippocampus."xsd:string |
| http://purl.uniprot.org/citations/22635104 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/22635104 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22635104 |
| http://purl.uniprot.org/citations/22635104 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22635104 |
| http://purl.uniprot.org/uniprot/P08069#attribution-F46DE870709B2C4A3565876261481E00 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22635104 |
| http://purl.uniprot.org/uniprot/P05019#attribution-50C1CA7C6E0B294F84A66F82B687C06C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22635104 |
| http://purl.uniprot.org/uniprot/P05019#attribution-F46DE870709B2C4A3565876261481E00 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22635104 |
| http://purl.uniprot.org/uniprot/P04629#attribution-0FED445E8F5CFA816F021F543711B996 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22635104 |
| http://purl.uniprot.org/uniprot/#_P08138-mappedCitation-22635104 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22635104 |
| http://purl.uniprot.org/uniprot/P08138 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22635104 |