| http://purl.uniprot.org/citations/22638550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22638550 | http://www.w3.org/2000/01/rdf-schema#comment | "Human T cell leukemia virus type 1 (HTLV-1) induced adult T cell leukemia/lymphoma (ATLL) is usually a fatal lymphoproliferative malignant disease. Thus, the enhancement of T cell immunity to ATLL through the development of therapeutic vaccines using characterized T cell peptide epitopes could be of value. We isolated and characterized HLA-DR-bound peptides from HTLV-1-transformed T cells by fractionating on reverse-phase high performance liquid chromatography and Edman NH(2)-terminal sequencing and were able to identify five independent peptide sequences. One of the identified peptide sequences corresponded to a fragment of the human interleukin-9 receptor alpha (IL-9Rα), which is commonly expressed by HTLV-1-infected T cell lymphoma cells. Using a synthetic peptide corresponding to the identified IL-9Rα sequence, we generated antigen-specific CD4 helper T lymphocytes in vitro, which were restricted by HLA-DR15 or HLA-DR53 molecules and could recognize and kill HTLV-1+, IL-9Rα+ T cell lymphoma cells. These results indicate that IL-9Rα functions as T cell leukemia/lymphoma-associated antigen for CD4 T cells and that synthetic peptides such as the one described here could be used for T cell-based immunotherapy against IL-9Rα positive ATLL."xsd:string |
| http://purl.uniprot.org/citations/22638550 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00262-012-1284-7"xsd:string |
| http://purl.uniprot.org/citations/22638550 | http://purl.uniprot.org/core/author | "Aoki N."xsd:string |
| http://purl.uniprot.org/citations/22638550 | http://purl.uniprot.org/core/author | "Hayashi S."xsd:string |
| http://purl.uniprot.org/citations/22638550 | http://purl.uniprot.org/core/author | "Kobayashi H."xsd:string |
| http://purl.uniprot.org/citations/22638550 | http://purl.uniprot.org/core/author | "Kimura S."xsd:string |
| http://purl.uniprot.org/citations/22638550 | http://purl.uniprot.org/core/author | "Matsuda Y."xsd:string |
| http://purl.uniprot.org/citations/22638550 | http://purl.uniprot.org/core/author | "Sato K."xsd:string |
| http://purl.uniprot.org/citations/22638550 | http://purl.uniprot.org/core/author | "Kumai T."xsd:string |
| http://purl.uniprot.org/citations/22638550 | http://purl.uniprot.org/core/author | "Celis E."xsd:string |
| http://purl.uniprot.org/citations/22638550 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22638550 | http://purl.uniprot.org/core/name | "Cancer Immunol Immunother"xsd:string |
| http://purl.uniprot.org/citations/22638550 | http://purl.uniprot.org/core/pages | "2215-2225"xsd:string |
| http://purl.uniprot.org/citations/22638550 | http://purl.uniprot.org/core/title | "A naturally processed HLA-DR-bound peptide from the IL-9 receptor alpha of HTLV-1-transformed T cells serves as a T helper epitope."xsd:string |
| http://purl.uniprot.org/citations/22638550 | http://purl.uniprot.org/core/volume | "61"xsd:string |
| http://purl.uniprot.org/citations/22638550 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22638550 |
| http://purl.uniprot.org/citations/22638550 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22638550 |
| http://purl.uniprot.org/uniprot/#_B4E011-mappedCitation-22638550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22638550 |
| http://purl.uniprot.org/uniprot/#_I6L9D8-mappedCitation-22638550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22638550 |
| http://purl.uniprot.org/uniprot/#_Q01113-mappedCitation-22638550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22638550 |
| http://purl.uniprot.org/uniprot/Q01113 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22638550 |
| http://purl.uniprot.org/uniprot/I6L9D8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22638550 |
| http://purl.uniprot.org/uniprot/B4E011 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22638550 |