| http://purl.uniprot.org/citations/22641034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22641034 | http://www.w3.org/2000/01/rdf-schema#comment | "The functions of Src family kinases are tightly regulated through Src homology (SH) domain-mediated protein-protein interactions. We previously reported the biophysical characteristics of the apoptosis-linked gene 2-interacting protein X (Alix) in complex with the haemopoietic cell kinase (Hck) SH3 domain. In the current study, we have combined ITC, NMR, SAXS and molecular modeling to determine a 3D model of the complex. We demonstrate that Hck SH3 recognizes an extended linear proline-rich region of Alix. This particular binding mode enables Hck SH3 to sense a specific non-canonical residue situated in the SH3 RT-loop of the kinase. The resulting model helps clarify the mechanistic insights of Alix-Hck interaction."xsd:string |
| http://purl.uniprot.org/citations/22641034 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2012.05.017"xsd:string |
| http://purl.uniprot.org/citations/22641034 | http://purl.uniprot.org/core/author | "Morelli X."xsd:string |
| http://purl.uniprot.org/citations/22641034 | http://purl.uniprot.org/core/author | "Shi X."xsd:string |
| http://purl.uniprot.org/citations/22641034 | http://purl.uniprot.org/core/author | "Martinez J."xsd:string |
| http://purl.uniprot.org/citations/22641034 | http://purl.uniprot.org/core/author | "Betzi S."xsd:string |
| http://purl.uniprot.org/citations/22641034 | http://purl.uniprot.org/core/author | "Huang M."xsd:string |
| http://purl.uniprot.org/citations/22641034 | http://purl.uniprot.org/core/author | "Zimmermann P."xsd:string |
| http://purl.uniprot.org/citations/22641034 | http://purl.uniprot.org/core/author | "Arold S.T."xsd:string |
| http://purl.uniprot.org/citations/22641034 | http://purl.uniprot.org/core/author | "Lecine P."xsd:string |
| http://purl.uniprot.org/citations/22641034 | http://purl.uniprot.org/core/author | "Collette Y."xsd:string |
| http://purl.uniprot.org/citations/22641034 | http://purl.uniprot.org/core/author | "Opi S."xsd:string |
| http://purl.uniprot.org/citations/22641034 | http://purl.uniprot.org/core/author | "Parrot I."xsd:string |
| http://purl.uniprot.org/citations/22641034 | http://purl.uniprot.org/core/author | "Lugari A."xsd:string |
| http://purl.uniprot.org/citations/22641034 | http://purl.uniprot.org/core/author | "Restouin A."xsd:string |
| http://purl.uniprot.org/citations/22641034 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22641034 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/22641034 | http://purl.uniprot.org/core/pages | "1759-1764"xsd:string |
| http://purl.uniprot.org/citations/22641034 | http://purl.uniprot.org/core/title | "Structural recognition mechanisms between human Src homology domain 3 (SH3) and ALG-2-interacting protein X (Alix)."xsd:string |
| http://purl.uniprot.org/citations/22641034 | http://purl.uniprot.org/core/volume | "586"xsd:string |
| http://purl.uniprot.org/citations/22641034 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22641034 |
| http://purl.uniprot.org/citations/22641034 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22641034 |
| http://purl.uniprot.org/uniprot/#_A8K4G3-mappedCitation-22641034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22641034 |
| http://purl.uniprot.org/uniprot/#_P03407-mappedCitation-22641034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22641034 |