| http://purl.uniprot.org/citations/22641383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22641383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22641383 | http://www.w3.org/2000/01/rdf-schema#comment | "Programmed cell death 1 (PD-1) is a negative costimulatory receptor critical for the suppression of T cell activation in vitro and in vivo. Single cell imaging elucidated a molecular mechanism of PD-1-mediated suppression. PD-1 becomes clustered with T cell receptors (TCRs) upon binding to its ligand PD-L1 and is transiently associated with the phosphatase SHP2 (Src homology 2 domain-containing tyrosine phosphatase 2). These negative costimulatory microclusters induce the dephosphorylation of the proximal TCR signaling molecules. This results in the suppression of T cell activation and blockade of the TCR-induced stop signal. In addition to PD-1 clustering, PD-1-TCR colocalization within microclusters is required for efficient PD-1-mediated suppression. This inhibitory mechanism also functions in PD-1(hi) T cells generated in vivo and can be overridden by a neutralizing anti-PD-L1 antibody. Therefore, PD-1 microcluster formation is important for regulation of T cell activation."xsd:string |
| http://purl.uniprot.org/citations/22641383 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20112741"xsd:string |
| http://purl.uniprot.org/citations/22641383 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20112741"xsd:string |
| http://purl.uniprot.org/citations/22641383 | http://purl.uniprot.org/core/author | "Saito T."xsd:string |
| http://purl.uniprot.org/citations/22641383 | http://purl.uniprot.org/core/author | "Saito T."xsd:string |
| http://purl.uniprot.org/citations/22641383 | http://purl.uniprot.org/core/author | "Azuma M."xsd:string |
| http://purl.uniprot.org/citations/22641383 | http://purl.uniprot.org/core/author | "Azuma M."xsd:string |
| http://purl.uniprot.org/citations/22641383 | http://purl.uniprot.org/core/author | "Yokosuka T."xsd:string |
| http://purl.uniprot.org/citations/22641383 | http://purl.uniprot.org/core/author | "Yokosuka T."xsd:string |
| http://purl.uniprot.org/citations/22641383 | http://purl.uniprot.org/core/author | "Takamatsu M."xsd:string |
| http://purl.uniprot.org/citations/22641383 | http://purl.uniprot.org/core/author | "Takamatsu M."xsd:string |
| http://purl.uniprot.org/citations/22641383 | http://purl.uniprot.org/core/author | "Hashimoto-Tane A."xsd:string |
| http://purl.uniprot.org/citations/22641383 | http://purl.uniprot.org/core/author | "Hashimoto-Tane A."xsd:string |
| http://purl.uniprot.org/citations/22641383 | http://purl.uniprot.org/core/author | "Kobayashi-Imanishi W."xsd:string |
| http://purl.uniprot.org/citations/22641383 | http://purl.uniprot.org/core/author | "Kobayashi-Imanishi W."xsd:string |
| http://purl.uniprot.org/citations/22641383 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22641383 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22641383 | http://purl.uniprot.org/core/name | "J. Exp. Med."xsd:string |
| http://purl.uniprot.org/citations/22641383 | http://purl.uniprot.org/core/name | "J. Exp. Med."xsd:string |
| http://purl.uniprot.org/citations/22641383 | http://purl.uniprot.org/core/pages | "1201-1217"xsd:string |
| http://purl.uniprot.org/citations/22641383 | http://purl.uniprot.org/core/pages | "1201-1217"xsd:string |
| http://purl.uniprot.org/citations/22641383 | http://purl.uniprot.org/core/title | "Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2."xsd:string |
| http://purl.uniprot.org/citations/22641383 | http://purl.uniprot.org/core/title | "Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2."xsd:string |