| http://purl.uniprot.org/citations/22645180 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22645180 | http://www.w3.org/2000/01/rdf-schema#comment | "Cytokine-induced expansion of hematopoietic stem and progenitor cells (HSPCs) is not fully understood. In the present study, we show that whereas steady-state hematopoiesis is normal in basic fibroblast growth factor (FGF-2)-knockout mice, parathyroid hormone stimulation and myeloablative treatments failed to induce normal HSPC proliferation and recovery. In vivo FGF-2 treatment expanded stromal cells, including perivascular Nestin(+) supportive stromal cells, which may facilitate HSPC expansion by increasing SCF and reducing CXCL12 via mir-31 up-regulation. FGF-2 predominantly expanded a heterogeneous population of undifferentiated HSPCs, preserving and increasing durable short- and long-term repopulation potential. Mechanistically, these effects were mediated by c-Kit receptor activation, STAT5 phosphorylation, and reduction of reactive oxygen species levels. Mice harboring defective c-Kit signaling exhibited abrogated HSPC expansion in response to FGF-2 treatment, which was accompanied by elevated reactive oxygen species levels. The results of the present study reveal a novel mechanism underlying FGF-2-mediated in vivo expansion of both HSPCs and their supportive stromal cells, which may be used to improve stem cell engraftment after clinical transplantation."xsd:string |
| http://purl.uniprot.org/citations/22645180 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2011-11-394692"xsd:string |
| http://purl.uniprot.org/citations/22645180 | http://purl.uniprot.org/core/author | "Berg T."xsd:string |
| http://purl.uniprot.org/citations/22645180 | http://purl.uniprot.org/core/author | "Lapidot T."xsd:string |
| http://purl.uniprot.org/citations/22645180 | http://purl.uniprot.org/core/author | "Kollet O."xsd:string |
| http://purl.uniprot.org/citations/22645180 | http://purl.uniprot.org/core/author | "Hornstein E."xsd:string |
| http://purl.uniprot.org/citations/22645180 | http://purl.uniprot.org/core/author | "Enikolopov G.N."xsd:string |
| http://purl.uniprot.org/citations/22645180 | http://purl.uniprot.org/core/author | "Piacibello W."xsd:string |
| http://purl.uniprot.org/citations/22645180 | http://purl.uniprot.org/core/author | "Kalinkovich A."xsd:string |
| http://purl.uniprot.org/citations/22645180 | http://purl.uniprot.org/core/author | "Itkin T."xsd:string |
| http://purl.uniprot.org/citations/22645180 | http://purl.uniprot.org/core/author | "Schajnovitz A."xsd:string |
| http://purl.uniprot.org/citations/22645180 | http://purl.uniprot.org/core/author | "Shezen E."xsd:string |
| http://purl.uniprot.org/citations/22645180 | http://purl.uniprot.org/core/author | "Ludin A."xsd:string |
| http://purl.uniprot.org/citations/22645180 | http://purl.uniprot.org/core/author | "Gradus B."xsd:string |
| http://purl.uniprot.org/citations/22645180 | http://purl.uniprot.org/core/author | "Coffin D.J."xsd:string |
| http://purl.uniprot.org/citations/22645180 | http://purl.uniprot.org/core/author | "Ovadya Y."xsd:string |
| http://purl.uniprot.org/citations/22645180 | http://purl.uniprot.org/core/author | "Canaani J."xsd:string |
| http://purl.uniprot.org/citations/22645180 | http://purl.uniprot.org/core/author | "Gur-Cohen S."xsd:string |
| http://purl.uniprot.org/citations/22645180 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22645180 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/22645180 | http://purl.uniprot.org/core/pages | "1843-1855"xsd:string |
| http://purl.uniprot.org/citations/22645180 | http://purl.uniprot.org/core/title | "FGF-2 expands murine hematopoietic stem and progenitor cells via proliferation of stromal cells, c-Kit activation, and CXCL12 down-regulation."xsd:string |
| http://purl.uniprot.org/citations/22645180 | http://purl.uniprot.org/core/volume | "120"xsd:string |
| http://purl.uniprot.org/citations/22645180 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22645180 |