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http://purl.uniprot.org/citations/22645431http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22645431http://www.w3.org/2000/01/rdf-schema#comment"

Background

Two major causes of gastric ulcers are Helicobacter pylori (H. pylori) infection and nonsteroidal anti-inflammatory drug (NSAID) use.

Aims

This study aimed to determine if there were different expressions of matrix metalloproteinases (MMPs) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) between H. pylori-infected and NSAID-related ulcers.

Methods

The 126 gastric ulcer patients (H. pylori infected n = 46; NSAID related n = 30; combined with two factors n = 50) provided ulcer and nonulcer tissues for assessment of MMP-3, -7, and -9 and TIMP-1 expression by immunohistochemical staining.

Results

Gastric ulcer tissues had significantly higher MMP-3, -7, and -9 and TIMP-1 expressions than nonulcer tissues (P < 0.05). H. pylori-infected gastric ulcers had even higher MMP-7, MMP-9, and TIMP-1 expressions in epithelial cells than NSAID-related gastric ulcers (P < 0.05). In patients with the two combined factors, gastric ulcers expressed similar proportions of antral ulcers and MMP-7 and MMP-9 intensities to NSAID-related gastric ulcers, but lower MMP-9 and TIMP-1 than H. pylori-infected gastric ulcers (P < 0.05).

Conclusions

H. pylori-infected gastric ulcers express higher MMP-7, MMP-9, and TIMP-1 than NSAID-related ulcers. In patients with the two combined factors, ulcer location and MMP-7 and MMP-9 intensities are similar to NSAID use."xsd:string
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http://purl.uniprot.org/citations/22645431http://purl.uniprot.org/core/author"Chen W.Y."xsd:string
http://purl.uniprot.org/citations/22645431http://purl.uniprot.org/core/author"Yang H.B."xsd:string
http://purl.uniprot.org/citations/22645431http://purl.uniprot.org/core/author"Chang W.L."xsd:string
http://purl.uniprot.org/citations/22645431http://purl.uniprot.org/core/author"Cheng H.C."xsd:string
http://purl.uniprot.org/citations/22645431http://purl.uniprot.org/core/author"Sheu B.S."xsd:string
http://purl.uniprot.org/citations/22645431http://purl.uniprot.org/core/author"Yeh Y.C."xsd:string
http://purl.uniprot.org/citations/22645431http://purl.uniprot.org/core/date"2012"xsd:gYear
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http://purl.uniprot.org/citations/22645431http://purl.uniprot.org/core/pages"539316"xsd:string
http://purl.uniprot.org/citations/22645431http://purl.uniprot.org/core/title"Expressions of MMPs and TIMP-1 in gastric ulcers may differentiate H. pylori-infected from NSAID-related ulcers."xsd:string
http://purl.uniprot.org/citations/22645431http://purl.uniprot.org/core/volume"2012"xsd:string
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