| http://purl.uniprot.org/citations/22648168 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22648168 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22648168 | http://www.w3.org/2000/01/rdf-schema#comment | "Cells rely on the coordinated regulation of lipid phosphoinositides and Rab GTPases to define membrane compartment fates along distinct trafficking routes. The family of disease-related myotubularin (MTM) phosphoinositide phosphatases includes catalytically inactive members, or pseudophosphatases, with poorly understood functions. We found that Drosophila MTM pseudophosphatase Sbf coordinates both phosphatidylinositol 3-phosphate (PI(3)P) turnover and Rab21 GTPase activation in an endosomal pathway that controls macrophage remodeling. Sbf dynamically interacts with class II phosphatidylinositol 3-kinase and stably recruits Mtm to promote turnover of a PI(3)P subpool essential for endosomal trafficking. Sbf also functions as a guanine nucleotide exchange factor that promotes Rab21 GTPase activation associated with PI(3)P endosomes. Of importance, Sbf, Mtm, and Rab21 function together, along with Rab11-mediated endosomal trafficking, to control macrophage protrusion formation. This identifies Sbf as a critical coordinator of PI(3)P and Rab21 regulation, which specifies an endosomal pathway and cortical control."xsd:string |
| http://purl.uniprot.org/citations/22648168 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e12-05-0375"xsd:string |
| http://purl.uniprot.org/citations/22648168 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e12-05-0375"xsd:string |
| http://purl.uniprot.org/citations/22648168 | http://purl.uniprot.org/core/author | "Cox S."xsd:string |
| http://purl.uniprot.org/citations/22648168 | http://purl.uniprot.org/core/author | "Cox S."xsd:string |
| http://purl.uniprot.org/citations/22648168 | http://purl.uniprot.org/core/author | "Jean S."xsd:string |
| http://purl.uniprot.org/citations/22648168 | http://purl.uniprot.org/core/author | "Jean S."xsd:string |
| http://purl.uniprot.org/citations/22648168 | http://purl.uniprot.org/core/author | "Robinson F.L."xsd:string |
| http://purl.uniprot.org/citations/22648168 | http://purl.uniprot.org/core/author | "Robinson F.L."xsd:string |
| http://purl.uniprot.org/citations/22648168 | http://purl.uniprot.org/core/author | "Schmidt E.J."xsd:string |
| http://purl.uniprot.org/citations/22648168 | http://purl.uniprot.org/core/author | "Schmidt E.J."xsd:string |
| http://purl.uniprot.org/citations/22648168 | http://purl.uniprot.org/core/author | "Kiger A."xsd:string |
| http://purl.uniprot.org/citations/22648168 | http://purl.uniprot.org/core/author | "Kiger A."xsd:string |
| http://purl.uniprot.org/citations/22648168 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22648168 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22648168 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/22648168 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/22648168 | http://purl.uniprot.org/core/pages | "2723-2740"xsd:string |
| http://purl.uniprot.org/citations/22648168 | http://purl.uniprot.org/core/pages | "2723-2740"xsd:string |
| http://purl.uniprot.org/citations/22648168 | http://purl.uniprot.org/core/title | "Sbf/MTMR13 coordinates PI(3)P and Rab21 regulation in endocytic control of cellular remodeling."xsd:string |
| http://purl.uniprot.org/citations/22648168 | http://purl.uniprot.org/core/title | "Sbf/MTMR13 coordinates PI(3)P and Rab21 regulation in endocytic control of cellular remodeling."xsd:string |
| http://purl.uniprot.org/citations/22648168 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/22648168 | http://purl.uniprot.org/core/volume | "23"xsd:string |