| http://purl.uniprot.org/citations/22652693 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22652693 | http://www.w3.org/2000/01/rdf-schema#comment | "Methylation of histone H3 at lysine 4 (H3K4) is a conserved feature of active chromatin catalyzed by methyltransferases of the SET1-family (SET1A, SET1B, MLL1, MLL2, MLL3 and MLL4 in humans). These enzymes participate in diverse gene regulatory networks with a multitude of known biological functions, including direct involvement in several human disease states. Unlike most lysine methyltransferases, SET1-family enzymes are only fully active in the context of a multi-subunit complex, which includes a protein module comprised of WDR5, RbBP5, ASH2L and DPY-30 (WRAD). These proteins bind in close proximity to the catalytic SET domain of SET1-family enzymes and stimulate H3K4 methyltransferase activity. The mechanism by which WRAD promotes catalysis involves elements of allosteric control and possibly the utilization of a second H3K4 methyltransferase active site present within WRAD itself. WRAD components also engage in physical interactions that recruit SET1-family proteins to target sites on chromatin. Here, the known molecular mechanisms through which WRAD enables the function of SET1-related enzymes will be reviewed."xsd:string |
| http://purl.uniprot.org/citations/22652693 | http://purl.org/dc/terms/identifier | "doi:10.1093/bfgp/els017"xsd:string |
| http://purl.uniprot.org/citations/22652693 | http://purl.uniprot.org/core/author | "Vakoc C.R."xsd:string |
| http://purl.uniprot.org/citations/22652693 | http://purl.uniprot.org/core/author | "Ernst P."xsd:string |
| http://purl.uniprot.org/citations/22652693 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22652693 | http://purl.uniprot.org/core/name | "Brief Funct Genomics"xsd:string |
| http://purl.uniprot.org/citations/22652693 | http://purl.uniprot.org/core/pages | "217-226"xsd:string |
| http://purl.uniprot.org/citations/22652693 | http://purl.uniprot.org/core/title | "WRAD: enabler of the SET1-family of H3K4 methyltransferases."xsd:string |
| http://purl.uniprot.org/citations/22652693 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/22652693 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22652693 |
| http://purl.uniprot.org/citations/22652693 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22652693 |
| http://purl.uniprot.org/uniprot/#_Q15291-mappedCitation-22652693 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22652693 |
| http://purl.uniprot.org/uniprot/#_P61964-mappedCitation-22652693 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22652693 |
| http://purl.uniprot.org/uniprot/#_Q9C005-mappedCitation-22652693 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22652693 |
| http://purl.uniprot.org/uniprot/#_Q9UBL3-mappedCitation-22652693 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22652693 |
| http://purl.uniprot.org/uniprot/Q15291 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22652693 |
| http://purl.uniprot.org/uniprot/Q9C005 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22652693 |
| http://purl.uniprot.org/uniprot/Q9UBL3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22652693 |
| http://purl.uniprot.org/uniprot/P61964 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22652693 |