| http://purl.uniprot.org/citations/22658724 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22658724 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22658724 | http://www.w3.org/2000/01/rdf-schema#comment | "DNA interstrand crosslinks (ICLs) are cytotoxic lesions that covalently link opposite strands of the DNA helix and block DNA unwinding. ICLs are repaired during and outside S phase, and replication-independent ICL repair (RIR) is critical to maintain genomic integrity and to allow transcription in nondividing or slowly dividing cells. Here, we show that the Y family DNA polymerase kappa (Pol κ) is essential for RIR of a site-specific ICL lesion in Xenopus egg extracts, and that both its catalytic activity and UBZ domains are required for this function. We also demonstrate a requirement for PCNA and its modification on lysine 164. Finally, we show that Pol κ participates in ICL repair in mammalian cells, particularly in G0. Our results identify key components of the RIR pathway and begin to unravel its mechanism."xsd:string |
| http://purl.uniprot.org/citations/22658724 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2012.05.001"xsd:string |
| http://purl.uniprot.org/citations/22658724 | http://purl.uniprot.org/core/author | "Gottesman M.E."xsd:string |
| http://purl.uniprot.org/citations/22658724 | http://purl.uniprot.org/core/author | "Gottesman M.E."xsd:string |
| http://purl.uniprot.org/citations/22658724 | http://purl.uniprot.org/core/author | "Gautier J."xsd:string |
| http://purl.uniprot.org/citations/22658724 | http://purl.uniprot.org/core/author | "Gautier J."xsd:string |
| http://purl.uniprot.org/citations/22658724 | http://purl.uniprot.org/core/author | "Williams H.L."xsd:string |
| http://purl.uniprot.org/citations/22658724 | http://purl.uniprot.org/core/author | "Williams H.L."xsd:string |
| http://purl.uniprot.org/citations/22658724 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22658724 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22658724 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/22658724 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/22658724 | http://purl.uniprot.org/core/pages | "140-147"xsd:string |
| http://purl.uniprot.org/citations/22658724 | http://purl.uniprot.org/core/pages | "140-147"xsd:string |
| http://purl.uniprot.org/citations/22658724 | http://purl.uniprot.org/core/title | "Replication-independent repair of DNA interstrand crosslinks."xsd:string |
| http://purl.uniprot.org/citations/22658724 | http://purl.uniprot.org/core/title | "Replication-independent repair of DNA interstrand crosslinks."xsd:string |
| http://purl.uniprot.org/citations/22658724 | http://purl.uniprot.org/core/volume | "47"xsd:string |
| http://purl.uniprot.org/citations/22658724 | http://purl.uniprot.org/core/volume | "47"xsd:string |
| http://purl.uniprot.org/citations/22658724 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22658724 |
| http://purl.uniprot.org/citations/22658724 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22658724 |
| http://purl.uniprot.org/citations/22658724 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22658724 |
| http://purl.uniprot.org/citations/22658724 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22658724 |
| http://purl.uniprot.org/uniprot/Q6DFE4 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/22658724 |