| http://purl.uniprot.org/citations/22659048 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22659048 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22659048 | http://www.w3.org/2000/01/rdf-schema#comment | "Saccharomyces cerevisiae is able to use some fatty acids, such as oleic acid, as a sole source of carbon. β-oxidation, which occurs in a single membrane-enveloped organelle or peroxisome, is responsible for the assimilation of fatty acids. In S. cerevisiae, β-oxidation occurs only in peroxisomes, and H(2)O(2) is generated during this fatty acid-metabolizing pathway. S. cerevisiae has three GPX genes (GPX1, GPX2, and GPX3) encoding atypical 2-Cys peroxiredoxins. Here we show that expression of GPX1 was induced in medium containing oleic acid as a carbon source in an Msn2/Msn4-dependent manner. We found that Gpx1 was located in the peroxisomal matrix. The peroxisomal Gpx1 showed peroxidase activity using thioredoxin or glutathione as a reducing power. Peroxisome biogenesis was induced when cells were cultured with oleic acid. Peroxisome biogenesis was impaired in gpx1∆ cells, and subsequently, the growth of gpx1∆ cells was lowered in oleic acid-containing medium. Gpx1 contains six cysteine residues. Of the cysteine-substituted mutants of Gpx1, Gpx1(C36S) was not able to restore growth and peroxisome formation in oleic acid-containing medium, therefore, redox regulation of Gpx1 seems to be involved in the mechanism of peroxisome formation."xsd:string |
| http://purl.uniprot.org/citations/22659048 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbalip.2012.05.004"xsd:string |
| http://purl.uniprot.org/citations/22659048 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbalip.2012.05.004"xsd:string |
| http://purl.uniprot.org/citations/22659048 | http://purl.uniprot.org/core/author | "Inoue Y."xsd:string |
| http://purl.uniprot.org/citations/22659048 | http://purl.uniprot.org/core/author | "Inoue Y."xsd:string |
| http://purl.uniprot.org/citations/22659048 | http://purl.uniprot.org/core/author | "Ohdate T."xsd:string |
| http://purl.uniprot.org/citations/22659048 | http://purl.uniprot.org/core/author | "Ohdate T."xsd:string |
| http://purl.uniprot.org/citations/22659048 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22659048 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22659048 | http://purl.uniprot.org/core/name | "Biochim. Biophys. Acta"xsd:string |
| http://purl.uniprot.org/citations/22659048 | http://purl.uniprot.org/core/name | "Biochim. Biophys. Acta"xsd:string |
| http://purl.uniprot.org/citations/22659048 | http://purl.uniprot.org/core/pages | "1295-1305"xsd:string |
| http://purl.uniprot.org/citations/22659048 | http://purl.uniprot.org/core/pages | "1295-1305"xsd:string |
| http://purl.uniprot.org/citations/22659048 | http://purl.uniprot.org/core/title | "Involvement of glutathione peroxidase 1 in growth and peroxisome formation in Saccharomyces cerevisiae in oleic acid medium."xsd:string |
| http://purl.uniprot.org/citations/22659048 | http://purl.uniprot.org/core/title | "Involvement of glutathione peroxidase 1 in growth and peroxisome formation in Saccharomyces cerevisiae in oleic acid medium."xsd:string |
| http://purl.uniprot.org/citations/22659048 | http://purl.uniprot.org/core/volume | "1821"xsd:string |
| http://purl.uniprot.org/citations/22659048 | http://purl.uniprot.org/core/volume | "1821"xsd:string |
| http://purl.uniprot.org/citations/22659048 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22659048 |
| http://purl.uniprot.org/citations/22659048 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22659048 |
| http://purl.uniprot.org/citations/22659048 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22659048 |
| http://purl.uniprot.org/citations/22659048 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22659048 |
| http://purl.uniprot.org/uniprot/P40581 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/22659048 |
| http://purl.uniprot.org/uniprot/P36014 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/22659048 |