| http://purl.uniprot.org/citations/22661093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22661093 | http://www.w3.org/2000/01/rdf-schema#comment | "In addition to a well-documented role in regulating T cell-mediated immune responses, B7-H3, a newly discovered member of the B7 superfamily, has been recently identified as a costimulator in the innate immunity-mediated inflammatory response. In this study, we further report that B7-H3 participates in the development of pneumococcal meningitis in a murine model. Exogenous administration of B7-H3 strongly amplified the inflammatory response, exacerbated blood-brain barrier disruption, and aggravated the clinical disease status in Streptococcus pneumoniae-infected C3H/HeN wild-type mice. Consistent with the in vivo findings, B7-H3 substantially augmented proinflammatory cytokine and chemokine production, upregulated NF-κB p65 and MAPK p38 phosphorylation, and enhanced the nuclear transactivation of NF-κB p65 at both TNF-α and IL-6 promoters in S. pneumoniae-stimulated primary murine microglia cells. These B7-H3-associated in vitro and in vivo effects appeared to be dependent on TLR2 signaling, as B7-H3 almost completely lost its amplifying actions in both TLR2-deficient microglial cells and TLR2-deficient mice. Furthermore, administration of the anti-B7-H3 mAb (MIH35) attenuated the inflammatory response and ameliorated blood-brain barrier disruption in S. pneumoniae-infected wild-type mice. Collectively, our results indicate that B7-H3 plays a contributory role in the development of S. pneumoniae infection-induced bacterial meningitis."xsd:string |
| http://purl.uniprot.org/citations/22661093 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1103715"xsd:string |
| http://purl.uniprot.org/citations/22661093 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/22661093 | http://purl.uniprot.org/core/author | "Feng X."xsd:string |
| http://purl.uniprot.org/citations/22661093 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/22661093 | http://purl.uniprot.org/core/author | "Wang J.H."xsd:string |
| http://purl.uniprot.org/citations/22661093 | http://purl.uniprot.org/core/author | "Ni H."xsd:string |
| http://purl.uniprot.org/citations/22661093 | http://purl.uniprot.org/core/author | "Redmond H.P."xsd:string |
| http://purl.uniprot.org/citations/22661093 | http://purl.uniprot.org/core/author | "Quinn E.M."xsd:string |
| http://purl.uniprot.org/citations/22661093 | http://purl.uniprot.org/core/author | "Blankson S."xsd:string |
| http://purl.uniprot.org/citations/22661093 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22661093 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/22661093 | http://purl.uniprot.org/core/pages | "347-355"xsd:string |
| http://purl.uniprot.org/citations/22661093 | http://purl.uniprot.org/core/title | "B7-H3 participates in the development of experimental pneumococcal meningitis by augmentation of the inflammatory response via a TLR2-dependent mechanism."xsd:string |
| http://purl.uniprot.org/citations/22661093 | http://purl.uniprot.org/core/volume | "189"xsd:string |
| http://purl.uniprot.org/citations/22661093 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22661093 |
| http://purl.uniprot.org/citations/22661093 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22661093 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SUD4-mappedCitation-22661093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22661093 |
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| http://purl.uniprot.org/uniprot/#_A6MDC5-mappedCitation-22661093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22661093 |
| http://purl.uniprot.org/uniprot/#_G3X8Y8-mappedCitation-22661093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22661093 |
| http://purl.uniprot.org/uniprot/#_Q811T5-mappedCitation-22661093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22661093 |
| http://purl.uniprot.org/uniprot/#_Q8K3D9-mappedCitation-22661093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22661093 |
| http://purl.uniprot.org/uniprot/#_Q9QUN7-mappedCitation-22661093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22661093 |