| http://purl.uniprot.org/citations/22661412 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22661412 | http://www.w3.org/2000/01/rdf-schema#comment | "Laminar organization is a key feature of the mammalian cerebral cortex, but the mechanisms by which final positioning and "inside-out" distribution of neurons are determined remain largely unknown. Here, we demonstrate that Robo1, a member of the family of Roundabout receptors, regulates the correct positioning of layers II/III pyramidal neurons in the neocortex. Specifically, we used RNA interference in mice to suppress the expression of Robo1 in a subset of layers II/III neurons, and observed the positions of these cells at distinct developmental stages. In contrast to control neurons that migrated toward the pial surface by P1, Robo1-suppressed neurons exhibited a delay in entering the cortical plate at respective stages. Unexpectedly, after the first postnatal week, these neurons were predominantly located in the upper part of layers II/III, in contrast to control cells that were distributed throughout these layers. Sequential electroporation studies revealed that Robo1-suppressed cells failed to establish the characteristic inside-out neuronal distribution and, instead, they accumulated beneath the marginal zone regardless of their birthdate. These results demonstrate that Robo receptors play a crucial role in neocortical lamination and particularly in the positioning of layers II/III pyramidal neurons."xsd:string |
| http://purl.uniprot.org/citations/22661412 | http://purl.org/dc/terms/identifier | "doi:10.1093/cercor/bhs141"xsd:string |
| http://purl.uniprot.org/citations/22661412 | http://purl.uniprot.org/core/author | "Namba T."xsd:string |
| http://purl.uniprot.org/citations/22661412 | http://purl.uniprot.org/core/author | "Kohsaka S."xsd:string |
| http://purl.uniprot.org/citations/22661412 | http://purl.uniprot.org/core/author | "Uchino S."xsd:string |
| http://purl.uniprot.org/citations/22661412 | http://purl.uniprot.org/core/author | "Nakajima K."xsd:string |
| http://purl.uniprot.org/citations/22661412 | http://purl.uniprot.org/core/author | "Gonda Y."xsd:string |
| http://purl.uniprot.org/citations/22661412 | http://purl.uniprot.org/core/author | "Tabata H."xsd:string |
| http://purl.uniprot.org/citations/22661412 | http://purl.uniprot.org/core/author | "Parnavelas J.G."xsd:string |
| http://purl.uniprot.org/citations/22661412 | http://purl.uniprot.org/core/author | "Hanashima C."xsd:string |
| http://purl.uniprot.org/citations/22661412 | http://purl.uniprot.org/core/author | "Andrews W.D."xsd:string |
| http://purl.uniprot.org/citations/22661412 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/22661412 | http://purl.uniprot.org/core/name | "Cereb Cortex"xsd:string |
| http://purl.uniprot.org/citations/22661412 | http://purl.uniprot.org/core/pages | "1495-1508"xsd:string |
| http://purl.uniprot.org/citations/22661412 | http://purl.uniprot.org/core/title | "Robo1 regulates the migration and laminar distribution of upper-layer pyramidal neurons of the cerebral cortex."xsd:string |
| http://purl.uniprot.org/citations/22661412 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/22661412 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22661412 |
| http://purl.uniprot.org/citations/22661412 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22661412 |
| http://purl.uniprot.org/uniprot/#_A0A338P6F7-mappedCitation-22661412 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22661412 |
| http://purl.uniprot.org/uniprot/#_A0A338P6U2-mappedCitation-22661412 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22661412 |
| http://purl.uniprot.org/uniprot/#_P70381-mappedCitation-22661412 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22661412 |
| http://purl.uniprot.org/uniprot/#_P70403-mappedCitation-22661412 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22661412 |
| http://purl.uniprot.org/uniprot/#_H3BJ26-mappedCitation-22661412 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22661412 |
| http://purl.uniprot.org/uniprot/#_H3BJL7-mappedCitation-22661412 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22661412 |