| http://purl.uniprot.org/citations/22665516 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22665516 | http://www.w3.org/2000/01/rdf-schema#comment | "Chaperones and foldases in the endoplasmic reticulum (ER) ensure correct protein folding. Extensive protein-protein interaction maps have defined the organization and function of many cellular complexes, but ER complexes are under-represented. Consequently, chaperone and foldase networks in the ER are largely uncharacterized. Using complementary ER-specific methods, we have mapped interactions between ER-lumenal chaperones and foldases and describe their organization in multiprotein complexes. We identify new functional chaperone modules, including interactions between protein-disulfide isomerases and peptidyl-prolyl cis-trans-isomerases. We have examined in detail a novel ERp72-cyclophilin B complex that enhances the rate of folding of immunoglobulin G. Deletion analysis and NMR reveal a conserved surface of cyclophilin B that interacts with polyacidic stretches of ERp72 and GRp94. Mutagenesis within this highly charged surface region abrogates interactions with its chaperone partners and reveals a new mechanism of ER protein-protein interaction. This ability of cyclophilin B to interact with different partners using the same molecular surface suggests that ER-chaperone/foldase partnerships may switch depending on the needs of different substrates, illustrating the flexibility of multichaperone complexes of the ER folding machinery."xsd:string |
| http://purl.uniprot.org/citations/22665516 | http://purl.org/dc/terms/identifier | "doi:10.1074/mcp.m111.016550"xsd:string |
| http://purl.uniprot.org/citations/22665516 | http://purl.uniprot.org/core/author | "Gehring K."xsd:string |
| http://purl.uniprot.org/citations/22665516 | http://purl.uniprot.org/core/author | "Thomas D.Y."xsd:string |
| http://purl.uniprot.org/citations/22665516 | http://purl.uniprot.org/core/author | "Jansen G."xsd:string |
| http://purl.uniprot.org/citations/22665516 | http://purl.uniprot.org/core/author | "Schade B."xsd:string |
| http://purl.uniprot.org/citations/22665516 | http://purl.uniprot.org/core/author | "Dejgaard K."xsd:string |
| http://purl.uniprot.org/citations/22665516 | http://purl.uniprot.org/core/author | "Denisov A.Y."xsd:string |
| http://purl.uniprot.org/citations/22665516 | http://purl.uniprot.org/core/author | "Maattanen P."xsd:string |
| http://purl.uniprot.org/citations/22665516 | http://purl.uniprot.org/core/author | "Chen L.Y."xsd:string |
| http://purl.uniprot.org/citations/22665516 | http://purl.uniprot.org/core/author | "Muller W.J."xsd:string |
| http://purl.uniprot.org/citations/22665516 | http://purl.uniprot.org/core/author | "Balghi H."xsd:string |
| http://purl.uniprot.org/citations/22665516 | http://purl.uniprot.org/core/author | "Scarffe L."xsd:string |
| http://purl.uniprot.org/citations/22665516 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22665516 | http://purl.uniprot.org/core/name | "Mol Cell Proteomics"xsd:string |
| http://purl.uniprot.org/citations/22665516 | http://purl.uniprot.org/core/pages | "710-723"xsd:string |
| http://purl.uniprot.org/citations/22665516 | http://purl.uniprot.org/core/title | "An interaction map of endoplasmic reticulum chaperones and foldases."xsd:string |
| http://purl.uniprot.org/citations/22665516 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/22665516 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22665516 |
| http://purl.uniprot.org/citations/22665516 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22665516 |
| http://purl.uniprot.org/uniprot/P06761#attribution-A9D5C96DC650980A949C13D0E60FBD6F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22665516 |
| http://purl.uniprot.org/uniprot/P18418#attribution-A9D5C96DC650980A949C13D0E60FBD6F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22665516 |
| http://purl.uniprot.org/uniprot/P35565#attribution-A9D5C96DC650980A949C13D0E60FBD6F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22665516 |
| http://purl.uniprot.org/uniprot/Q66HD0#attribution-A9D5C96DC650980A949C13D0E60FBD6F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22665516 |